Spenlé C, Hussenet T, Lacroute J, Lefebvre O, Kedinger M, Orend G, Simon-Assmann P
Inserm, U682, Homeostasis of the tissue to cancer and inflammation, 3, avenue Molière, 67200 Strasbourg, France.
Pathol Biol (Paris). 2012 Feb;60(1):41-7. doi: 10.1016/j.patbio.2011.10.005. Epub 2011 Nov 17.
Laminins are structural components of basement membranes that regulate and control many cellular functions. Changes in basement membrane composition play significant roles in etiology of diseases. Inflammatory bowel diseases are conditions that lead to defects in the mucosal barrier which includes the basement membrane underlying the epithelium. This review will summarize the main findings related to the involvement of laminins and of the laminin-binding receptors in inflammatory conditions such as Crohn's disease and ulcerative colitis. We will review the current literature devoted to studies in humans (immunolocalisation, genetic factors, microarray data), as well as experimental cell models that show that laminins contribute to the inflammation process probably linked to the deregulation of proinflammatory cytokines.
层粘连蛋白是基底膜的结构成分，可调节和控制许多细胞功能。基底膜组成的变化在疾病病因学中起重要作用。炎症性肠病会导致黏膜屏障缺陷，其中包括上皮细胞下方的基底膜。本综述将总结与层粘连蛋白及层粘连蛋白结合受体参与克罗恩病和溃疡性结肠炎等炎症性疾病相关的主要研究结果。我们将回顾目前有关人类研究（免疫定位、遗传因素、微阵列数据）的文献，以及实验性细胞模型，这些研究表明层粘连蛋白可能通过促炎细胞因子失调参与炎症过程。
