Miner Jeffrey H
Renal Division and Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Microsc Res Tech. 2008 May;71(5):349-56. doi: 10.1002/jemt.20563.
Laminins are alpha-beta-gamma heterotrimeric components of all basement membranes. Laminins are now known to play the central role in organizing and establishing the basement membrane. The diversity of laminins allows them to impart special structural and signaling properties to the basement membrane. Of the 12 known laminin chain genes, 10 have been either found to be mutated in humans or experimentally mutated in mice. This has led to great progress over the last several years towards understanding both the functions of laminins and the reasons for their great diversity. In this review, I will summarize the in vivo studies in mice and humans that have contributed to this new knowledge.
层粘连蛋白是所有基底膜的α-β-γ异源三聚体成分。现在已知层粘连蛋白在组织和建立基底膜中起核心作用。层粘连蛋白的多样性使其能够赋予基底膜特殊的结构和信号特性。在已知的12个层粘连蛋白链基因中，有10个已被发现人类发生突变或在小鼠中进行了实验性突变。在过去几年中，这在理解层粘连蛋白的功能及其多样性的原因方面取得了巨大进展。在这篇综述中，我将总结在小鼠和人类中有助于这一新知识的体内研究。
