National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA.
Nat Neurosci. 2011 Nov 20;15(1):23-5. doi: 10.1038/nn.2962.
Caffeine enhances cognition, but even high non-physiological doses have modest effects on synapses. A(1) adenosine receptors (A(1)Rs) are antagonized by caffeine and are most highly enriched in hippocampal CA2, which has not been studied in this context. We found that physiological doses of caffeine in vivo or A(1)R antagonists in vitro induced robust, long-lasting potentiation of synaptic transmission in rat CA2 without affecting other regions of the hippocampus.
咖啡因可增强认知能力，但即使是高非生理剂量也只能对突触产生适度影响。咖啡因可拮抗 A1 腺苷受体（A1Rs），而 A1Rs 在海马 CA2 区最为丰富，但目前尚未对此进行研究。我们发现，体内给予生理剂量的咖啡因或体外使用 A1R 拮抗剂均可诱导大鼠 CA2 区突触传递的持久增强，而不影响海马的其他区域。
