Pillai Rishvini Kailashnath, Pillai Roshvin Kailashnath, Illankovan Vinibha Rajakumari, Kumarasamy Vinoth, Reddy Satyanarayana, Gowtham K, Dhanasekaran Muralikrishnan, Subramaniyan Vetriselvan
Faculty of Medicine, MAHSA University Jalan SP 2, Bandar Saujana Putra, Jenjarom, Selangor 42610, Malaysia.
Centre for Pre-University Studies, MAHSA University Jalan SP 2, Bandar Saujana Putra, Jenjarom, Selangor 42610, Malaysia.
Toxicol Rep. 2024 Sep 27;13:101754. doi: 10.1016/j.toxrep.2024.101754. eCollection 2024 Dec.
Globally, Strongyloides stercoralis is a prevalent nematode parasite infecting over 600 million individuals, predominantly in tropical regions. Despite its widespread occurrence, it is frequently underdiagnosed and neglected, posing significant health risks, particularly to immunocompromised individuals. This parasite's life cycle includes a concerning capability for autoinfection, potentially leading to hyperinfection syndrome with high mortality rates. Alcoholism is recognized as a major risk factor for exacerbating S. stercoralis infections due to its harmful impact on the immune system. Chronic alcohol consumption impairs adaptive immunity by reducing T-cell and B-cell function, which facilitates parasitic infections. This review examines the complex relationship between alcohol abuse and strongyloidiasis, emphasizing the molecular mechanisms involved. Diagnostic challenges and treatment options, particularly the efficacy of antiparasitic drugs like ivermectin, are also discussed. Understanding these interactions is essential for developing improved diagnostic and therapeutic strategies to combat strongyloidiasis, especially among vulnerable populations, highlighting areas for future study.
在全球范围内，粪类圆线虫是一种普遍存在的线虫寄生虫，感染人数超过6亿，主要分布在热带地区。尽管其广泛存在，但它经常被漏诊和忽视，带来重大健康风险，尤其是对免疫功能低下的个体。这种寄生虫的生命周期包括自身感染的能力，这可能导致高死亡率的超感染综合征。酗酒被认为是加重粪类圆线虫感染的主要风险因素，因为它对免疫系统有有害影响。长期饮酒会通过降低T细胞和B细胞功能来损害适应性免疫，从而促进寄生虫感染。本综述探讨了酒精滥用与类圆线虫病之间的复杂关系，强调了其中涉及的分子机制。还讨论了诊断挑战和治疗选择，特别是伊维菌素等抗寄生虫药物的疗效。了解这些相互作用对于制定改进的诊断和治疗策略以对抗类圆线虫病至关重要，尤其是在弱势群体中，突出了未来的研究领域。
