Unité de Recherche, Service Universitaire de Psychiatrie de l'Enfant et de l'Adolescent (SUPEA), Centre Hospitalier Universitaire Vaudois (CHUV), Route du Bugnon 25A, 1011, Lausanne, Switzerland.
Psychiatr Q. 2012 Sep;83(3):311-24. doi: 10.1007/s11126-011-9201-3.
Twenty-three adolescents with psychotic disorders, aged from 13 to 18 years, participated in a 12-week open label trial (17 adolescents completed the study) in order to examine the impact of quetiapine on clinical status and cognitive functions (encompassing processing speed, attention, short-term memory, long-term memory and executive function). An improvement in Clinical Global Impression and Positive and Negative Symptom Scale (P's ≤ 0.001) was observed. In addition, after controlling for amelioration of symptoms, a significant improvement was observed on one executive function (P = 0.044; Trail Making Part B). The remaining cognitive abilities showed stability. In addition, we observed an interaction between quetiapine doses (>300 mg/day or <300 mg/day) and time, where lower doses showed more improvement in verbal short-term memory (P = 0.048), inhibition abilities (P = 0.038) and positive symptoms (P = 0.020). The neuropsychological functioning of adolescents with psychotic disorders remained mainly stable after 12 weeks of treatment with quetiapine. However, lower doses seemed to have a better impact on two components of cognition (inhibition abilities and verbal short-term memory) and on positive symptoms.
23 名患有精神病的青少年（年龄 13 至 18 岁）参加了一项为期 12 周的开放标签试验（17 名青少年完成了该研究），以检验喹硫平对临床状况和认知功能（包括处理速度、注意力、短期记忆、长期记忆和执行功能）的影响。观察到临床总体印象和阳性与阴性症状量表（P 值均 ≤ 0.001）的改善。此外，在控制症状改善的情况下，还观察到执行功能（P = 0.044；TMT 测试 B 部分）有显著改善。其他认知能力保持稳定。此外，我们还观察到喹硫平剂量（>300mg/天或<300mg/天）和时间之间的相互作用，较低剂量在言语短期记忆（P = 0.048）、抑制能力（P = 0.038）和阳性症状（P = 0.020）方面显示出更大的改善。在接受喹硫平治疗 12 周后，青少年精神病患者的神经心理功能基本保持稳定。然而，较低剂量似乎对认知的两个方面（抑制能力和言语短期记忆）以及阳性症状有更好的影响。
