Sandilyan Malarvizhi Babu, Dening Tom
Cambridgeshire and Peterborough NHS Foundation Trust, Old Age Psychiatry, Beechcroft, Fulbourn Hospital, UK.
Menopause Int. 2011 Dec;17(4):142-7. doi: 10.1258/mi.2011.011102. Epub 2011 Nov 18.
The menopause is a time in a woman's life when it is recognized that biological and social changes can impact upon mental wellbeing. Several studies have investigated the relationship between menopause and psychological symptoms, especially depression, with mixed results. In part, this is due to a considerable overlap between depressive symptoms and those due to declining estrogen levels, causing challenges in assessment. However it appears that vulnerable women are at a higher risk of succumbing to depression during menopausal transition. Antidepressants remain the mainstay of treating depressive symptoms, with little conclusive evidence for hormone replacement therapy. Memory problems during menopause are a common complaint, but there is no demonstrated link to subsequent dementia. This paper also reviews considerations of diagnosis and treatment of postmenopausal depression.
更年期是女性生命中的一个阶段，在此期间，人们认识到生物和社会变化会影响心理健康。多项研究调查了更年期与心理症状，尤其是抑郁症之间的关系，结果不一。部分原因是抑郁症状与雌激素水平下降所致症状有相当大的重叠，这给评估带来了挑战。然而，似乎处于更年期过渡阶段的脆弱女性更容易患上抑郁症。抗抑郁药仍然是治疗抑郁症状的主要手段，而激素替代疗法几乎没有确凿证据。更年期期间的记忆问题是常见的主诉，但尚无证据表明与随后的痴呆症有关。本文还综述了绝经后抑郁症的诊断和治疗要点。
