新德里金属β-内酰胺酶1（NDM-1）的结构
Structure of New Delhi metallo-β-lactamase 1 (NDM-1).
作者信息
Green Victoria L, Verma Anil, Owens Raymond J, Phillips Simon E V, Carr Stephen B
机构信息
Research Complex at Harwell, Rutherford Appleton Laboratory, Harwell Oxford, Didcot, Oxon OX11 0FA, England.
出版信息
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1160-4. doi: 10.1107/S1744309111029654. Epub 2011 Sep 6.
Abstract
Antibiotic resistance in bacterial pathogens poses a serious threat to human health and the metallo-β-lactamase (MBL) enzymes are responsible for much of this resistance. The recently identified New Delhi MBL 1 (NDM-1) is a novel member of this family that is capable of hydrolysing a wide variety of clinically important antibiotics. Here, the crystal structure of NDM-1 from Klebsiella pneumoniae is reported and its structure and active site are discussed in the context of other recently deposited coordinates of NDM-1.
摘要
细菌病原体中的抗生素耐药性对人类健康构成严重威胁，金属β-内酰胺酶（MBL）酶在很大程度上导致了这种耐药性。最近发现的新德里金属β-内酰胺酶1（NDM-1）是该家族的一个新成员，能够水解多种临床上重要的抗生素。本文报道了肺炎克雷伯菌中NDM-1的晶体结构，并结合最近存入的其他NDM-1坐标讨论了其结构和活性位点。
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