Doping Control Laboratory, Seibersdorf Labor GmbH, 2444 Seibersdorf, Austria.
Drug Test Anal. 2011 Nov-Dec;3(11-12):814-9. doi: 10.1002/dta.373. Epub 2011 Nov 18.
In the present study, the content of a number of black market testosterone products collected in Austria has been analyzed. Additionally, (13) C/(12) C ratios were measured for testosterone in the products after cleavage of the testosterone ester. The aim was to determine whether some of these products had similar (13) C/(12) C ratios to those normally found for endogenous testosterone, which could prevent a positive isotopic ratio mass spectrometric (IRMS) finding in doping control. Moreover, it was investigated to what extent the preparations contained the masking agent epitestosterone, in order to lower the testosterone/epitestosterone (T/E) ratio in urinary steroid profiles. Out of 30 analyzed products, the declared ingredients differed from the actual content in 10 cases. Epitestosterone, however, could not be found in any of the products. The products displayed δ(13)C(VPDB) values between -23.6 and -29.4‰. For more than half of these products, the values were within a range reported for endogenous urinary steroids.
在本研究中，对在奥地利收集的一些黑市睾酮产品的含量进行了分析。此外，还对产品中的睾酮酯进行裂解后测量了 (13)C/(12)C 比值。目的是确定这些产品中的一些是否与内源性睾酮的正常 (13)C/(12)C 比值相似，从而防止在兴奋剂控制中出现同位素比质谱 (IRMS) 阳性发现。此外，还研究了这些制剂中掩蔽剂表睾酮的含量，以降低尿类固醇谱中的睾酮/表睾酮 (T/E) 比值。在所分析的 30 种产品中，有 10 种产品的宣称成分与实际成分不符。然而，在任何一种产品中都没有发现表睾酮。这些产品的 δ(13)C(VPDB) 值在-23.6 到-29.4‰之间。对于其中一半以上的产品，这些值在报告的内源性尿类固醇范围内。
