Nehra A, Mullick F, Ishak K G, Zimmerman H J
Veterans Administration Medical Center, Washington, D.C.
Gastroenterology. 1990 Nov;99(5):1517-9. doi: 10.1016/0016-5085(90)91186-a.
Among 100 cases of hepatic injury attributed to the administration of pemoline, 43 had sufficient accompanying information to permit analysis. All but two patients were less than 20 years old, and 80% were less than 12 years old. Males predominated the study. Injury appeared as early as 1 week or as late as greater than 1 year of taking the drug. The injury was uniformly hepatocellular as judged by the high values for aminotransferases and by death in massive necrosis in one patient. Mechanism was judged to be idiosyncratic, and the idiosyncrasy was probably metabolic rather than immunologic.
在100例因服用匹莫林导致肝损伤的病例中，43例有足够的伴随信息可供分析。除两名患者外，所有患者年龄均小于20岁，80%的患者年龄小于12岁。研究以男性为主。损伤最早出现在服药1周后，最晚出现在服药1年多后。根据转氨酶的高值以及1例患者因大块坏死死亡判断，损伤均为肝细胞性。其机制被判定为特异质性，且这种特异质性可能是代谢性的而非免疫性的。
