支柱文章：一种潜在细胞质转录因子的干扰素依赖性酪氨酸磷酸化。《科学》。1992年。第257卷：第809 - 813页。 - Suppr

Suppr

超能文献

Pillars article: Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science. 1992. 257: 809-813.

作者信息

Schindler Chris, Shuai Ke, Prezioso Vincent R, Darnell James E

出版信息

J Immunol. 2011 Dec 1;187(11):5489-94.

PMID:22102732

Abstract

摘要

相似文献

Pillars article: Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science. 1992. 257: 809-813.支柱文章：一种潜在细胞质转录因子的干扰素依赖性酪氨酸磷酸化。《科学》。1992年。第257卷：第809 - 813页。

J Immunol. 2011 Dec 1;187(11):5489-94.

Cytokine signaling: birth of a pathway.细胞因子信号传导：一条信号通路的诞生

J Immunol. 2011 Dec 1;187(11):5475-8. doi: 10.4049/jimmunol.1102913.

Induction of expression of interferon-stimulated gene factor-3 (ISGF-3) proteins by interferons.干扰素对干扰素刺激基因因子-3（ISGF-3）蛋白表达的诱导作用。

Exp Cell Res. 1995 Jan;216(1):143-8. doi: 10.1006/excr.1995.1018.

Counter-regulation mechanism of IL-4 and IFN-α signal transduction through cytosolic retention of the pY-STAT6:pY-STAT2:p48 complex.通过 pY-STAT6:pY-STAT2:p48 复合物的细胞溶质保留来调节 IL-4 和 IFN-α 信号转导的反调节机制。

Eur J Immunol. 2011 Feb;41(2):461-72. doi: 10.1002/eji.201040668. Epub 2010 Dec 29.

Molecular mechanisms regulating induction of interleukin-6 gene transcription by interferon-gamma.

Eur J Immunol. 1997 Nov;27(11):3022-30. doi: 10.1002/eji.1830271140.

Inhibition of interferon gamma signaling by the short chain fatty acid butyrate.短链脂肪酸丁酸对γ-干扰素信号传导的抑制作用。

Mol Cancer Res. 2003 Sep;1(11):855-62.

The two interfaces of the STAT1 N-terminus exhibit opposite functions in IFNγ-regulated gene expression.信号转导和转录激活因子1（STAT1）N端的两个界面在γ干扰素调节的基因表达中表现出相反的功能。

Mol Immunol. 2015 Oct;67(2 Pt B):596-606. doi: 10.1016/j.molimm.2015.07.015. Epub 2015 Aug 11.

Dephosphorylation failure of tyrosine-phosphorylated STAT1 in IFN-stimulated Sendai virus C protein-expressing cells.在表达仙台病毒C蛋白的干扰素刺激细胞中，酪氨酸磷酸化的STAT1去磷酸化失败。

Virology. 2002 Feb 15;293(2):205-9. doi: 10.1006/viro.2001.1250.

Involvement of tyrosine phosphatase PTP1D in the inhibition of interleukin-6-induced Stat3 signaling by alpha-thrombin.酪氨酸磷酸酶PTP1D参与α-凝血酶对白细胞介素-6诱导的Stat3信号传导的抑制作用。

Biochem Biophys Res Commun. 2001 Oct 19;288(1):252-7. doi: 10.1006/bbrc.2001.5759.

TGF-beta suppression of IFN-gamma-induced class II MHC gene expression does not involve inhibition of phosphorylation of JAK1, JAK2, or signal transducers and activators of transcription, or modification of IFN-gamma enhanced factor X expression.转化生长因子β对γ干扰素诱导的Ⅱ类主要组织相容性复合体基因表达的抑制作用，并不涉及对JAK1、JAK2或信号转导子及转录激活子磷酸化的抑制，也不涉及γ干扰素增强因子X表达的改变。

J Immunol. 1995 Jan 15;154(2):610-9.

引用本文的文献

Elevated Type I Interferon Signaling Defines the Proliferative Advantage of ARF and p53 Mutant Tumor Cells.I型干扰素信号升高决定了ARF和p53突变肿瘤细胞的增殖优势。

Mol Cell Biol. 2025;45(6):246-261. doi: 10.1080/10985549.2025.2497817. Epub 2025 May 12.

STAT Signature Dish: Serving Immunity with a Side of Dietary Control.STAT特色菜品：提供免疫力并辅以饮食控制。

Biomolecules. 2025 Mar 26;15(4):487. doi: 10.3390/biom15040487.

Signaling by Type I Interferons in Immune Cells: Disease Consequences.免疫细胞中I型干扰素的信号传导：疾病后果

Cancers (Basel). 2024 Apr 22;16(8):1600. doi: 10.3390/cancers16081600.

The Curcumin Analogs 2-Pyridyl Cyclohexanone Induce Apoptosis via Inhibition of the JAK2-STAT3 Pathway in Human Esophageal Squamous Cell Carcinoma Cells.姜黄素类似物2-吡啶基环己酮通过抑制人食管鳞状细胞癌细胞中的JAK2-STAT3通路诱导细胞凋亡。

Front Pharmacol. 2018 Aug 21;9:820. doi: 10.3389/fphar.2018.00820. eCollection 2018.

Red wine polyphenol extract efficiently protects intestinal epithelial cells from inflammation opposite modulation of JAK/STAT and Nrf2 pathways.红酒多酚提取物通过对JAK/STAT和Nrf2通路的反向调节，有效保护肠上皮细胞免受炎症侵害。

Toxicol Res (Camb). 2015 Oct 5;5(1):53-65. doi: 10.1039/c5tx00214a. eCollection 2016 Jan 1.

Fine-tuning type I IFN signaling: A new chapter in the IFN saga.微调 I 型干扰素信号：干扰素传奇的新篇章。

Cell Res. 2017 Dec;27(12):1407-1408. doi: 10.1038/cr.2017.118. Epub 2017 Sep 19.

Canonical and non-canonical JAK-STAT signaling.经典和非经典JAK-STAT信号传导。

Trends Cell Biol. 2008 Nov;18(11):545-51. doi: 10.1016/j.tcb.2008.08.008. Epub 2008 Oct 9.

STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity.造血过程中 STAT3 的缺失会导致克罗恩病样发病机制和致死率：STAT3 在固有免疫中的关键作用

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1879-84. doi: 10.1073/pnas.0237137100. Epub 2003 Feb 5.

IFNalpha/beta promotes cell survival by activating NF-kappa B.干扰素α/β通过激活核因子κB来促进细胞存活。

Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13631-6. doi: 10.1073/pnas.250477397.

Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain.Stat1的核质转运由卷曲螺旋结构域中富含亮氨酸的输出信号调控。

Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10418-23. doi: 10.1073/pnas.190318397.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验