Cytokine signaling: birth of a pathway.
作者信息
O'Shea John J, Gadina Massimo, Kanno Yuka
机构信息
National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutesof Health, Bethesda, MD 20892, USA.
出版信息
J Immunol. 2011 Dec 1;187(11):5475-8. doi: 10.4049/jimmunol.1102913.
Abstract
摘要
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Cytokine signaling: birth of a pathway.细胞因子信号传导：一条信号通路的诞生
J Immunol. 2011 Dec 1;187(11):5475-8. doi: 10.4049/jimmunol.1102913.
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Luteolin sensitizes the antiproliferative effect of interferon α/β by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in cancer cells.木樨草素通过蛋白激酶 A 介导的蛋白酪氨酸磷酸酶 SHP-2 抑制作用激活 Janus 激酶/信号转导和转录激活因子通路信号，从而增强干扰素 α/β 的抗肿瘤增殖作用。
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Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis.功能获得性人类 STAT1 突变会损害 IL-17 免疫，并导致慢性黏膜皮肤念珠菌病。
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Genomic views of STAT function in CD4+ T helper cell differentiation.STAT 功能在 CD4+T 辅助细胞分化中的基因组学观点。
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Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease.1q32 和 STAT3 变异与强直性脊柱炎的关联提示其与克罗恩病存在遗传重叠。
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N Engl J Med. 2010 Sep 16;363(12):1117-27. doi: 10.1056/NEJMoa1002028.
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Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation.信号转导和转录激活因子4（STAT4）和信号转导和转录激活因子6（STAT6）转录因子在调节辅助性T细胞分化过程中的表观遗传修饰和转录中的离散作用。
Immunity. 2010 Jun 25;32(6):840-51. doi: 10.1016/j.immuni.2010.06.003.
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Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.STAT4 作为一种常见的自身免疫基因的证据：rs7574865 与结肠克罗恩病和疾病早发相关。
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Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.线粒体 STAT3 支持 Ras 依赖性致癌转化。
Science. 2009 Jun 26;324(5935):1713-6. doi: 10.1126/science.1171721.
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Janus kinases in immune cell signaling.免疫细胞信号传导中的 Janus 激酶
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Function of mitochondrial Stat3 in cellular respiration.线粒体Stat3在细胞呼吸中的功能。
Science. 2009 Feb 6;323(5915):793-7. doi: 10.1126/science.1164551. Epub 2009 Jan 8.
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