College of Pharmacy, Southwestern Oklahoma State University, Weatherford, 73096, USA.
Am J Pharm Educ. 2011 Oct 10;75(8):161. doi: 10.5688/ajpe758161.
The origins and advancements of pharmacy, medicinal chemistry, and drug discovery are interwoven in nature. Medicinal chemistry provides pharmacy students with a thorough understanding of drug mechanisms of action, structure-activity relationships (SAR), acid-base and physicochemical properties, and absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles. A comprehensive understanding of the chemical basis of drug action equips pharmacy students with the ability to answer rationally the "why" and "how" questions related to drug action and it sets the pharmacist apart as the chemical expert among health care professionals. By imparting an exclusive knowledge base, medicinal chemistry plays a vital role in providing critical thinking and evidence-based problem-solving skills to pharmacy students, enabling them to make optimal patient-specific therapeutic decisions. This review highlights the parallel nature of the history of pharmacy and medicinal chemistry, as well as the key elements of medicinal chemistry and drug discovery that make it an indispensable component of the pharmacy curriculum.
药学、药物化学和药物发现的起源和发展在本质上是交织在一起的。药物化学为药学学生提供了对药物作用机制、构效关系(SAR)、酸碱和物理化学性质以及吸收、分布、代谢、排泄和毒性(ADMET)特征的全面理解。对药物作用的化学基础的全面理解使药学学生能够合理回答与药物作用相关的“为什么”和“如何”的问题,并使药剂师成为医疗保健专业人员中的化学专家。通过传授独特的知识库,药物化学在为药学学生提供批判性思维和基于证据的问题解决技能方面发挥着至关重要的作用,使他们能够为患者做出最佳的个体化治疗决策。本文综述强调了药学和药物化学历史的并行性质,以及药物化学和药物发现的关键要素,这些要素使它成为药学课程不可或缺的组成部分。