Mani Vigneshwaran, Chikkaveeraiah Bhaskara V, Rusling James F
Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, Connecticut 06269.
Expert Opin Med Diagn. 2011 Sep 1;5(5):381-391. doi: 10.1517/17530059.2011.607161.
Devices for the reliable detection of panels of biomarker proteins facilitated by magnetic bead-based technologies have the potential to greatly improve future cancer diagnostics. The reason for this review is to highlight promising research on emerging procedures for protein capture, transport and detection featuring magnetic particles. AREAS COVERED IN THIS REVIEW: The review covers applications of magnetic particles in protein immunoassays in emerging research and commercial methods, and stresses multiplexed protein assays for reliable future cancer diagnostics. Research literature over the past dozen years has been surveyed and specific examples are presented in detail. EXPERT OPINION: Magnetic particles are important components of emerging protein detection systems. They need to be integrated into simple inexpensive systems for accurate, sensitive detection of fully validated panels of biomarker proteins to be widely useful in clinical cancer diagnostics.
基于磁珠技术的用于可靠检测生物标志物蛋白组的设备有潜力极大地改善未来的癌症诊断。进行本综述的原因是突出关于以磁性颗粒为特色的蛋白质捕获、转运和检测新方法的有前景的研究。本综述涵盖的领域：该综述涵盖了磁性颗粒在新兴研究和商业方法中的蛋白质免疫测定中的应用，并强调用于未来可靠癌症诊断的多重蛋白质测定。对过去十二年的研究文献进行了调查，并详细列举了具体实例。专家观点：磁性颗粒是新兴蛋白质检测系统的重要组成部分。它们需要被整合到简单廉价的系统中，以便准确、灵敏地检测经过充分验证的生物标志物蛋白组，从而在临床癌症诊断中广泛应用。
