Perera Harini A, Yan Mingdi
Department of Chemistry, University of Massachusetts Lowell, Lowell, MA, 01854, USA.
Top Curr Chem (Cham). 2021 Apr 9;379(3):21. doi: 10.1007/s41061-021-00333-x.
Microorganisms, including bacteria, viruses and fungi, are ubiquitous in nature. Some are extremely beneficial to life on Earth, whereas some cause diseases and disrupt normal human physiology. Pathogenic microorganisms can also undergo mutations and develop resistance to antimicrobial agents, which complicates diagnostic and therapeutic regimens. This calls for continuing efforts to develop new strategies and tools that can provide fast, sensitive and accurate diagnosis, as well as effective treatment of ever-evolving infectious diseases. Aggregation-induced emission luminogens (AIEgens) have shown promise in imaging, identification and inhibition of various microbial species. Compared to conventional organic fluorophores, AIEgens can offer improved photostability, and have found utilities in imaging microorganisms. AIEgens have been shown to detect microbial viability and differentiate among different microbial strains. Theranostic AIEgens that integrate imaging and killing of microbes have also been developed. This review highlights examples in the literature where AIEgens have been employed as molecular probes in the imaging, discrimination and killing of bacteria, viruses and fungi.
包括细菌、病毒和真菌在内的微生物在自然界中无处不在。有些对地球上的生命极其有益，而有些则会引发疾病并扰乱人体正常生理机能。致病微生物还会发生突变并产生对抗菌剂的耐药性，这使得诊断和治疗方案变得复杂。这就需要持续努力开发新的策略和工具，以实现对不断演变的传染病进行快速、灵敏且准确的诊断以及有效的治疗。聚集诱导发光材料（AIEgens）在各种微生物的成像、识别和抑制方面展现出了潜力。与传统有机荧光团相比，AIEgens具有更高的光稳定性，并已应用于微生物成像。AIEgens已被证明可检测微生物的活力并区分不同的微生物菌株。还开发了兼具成像和杀灭微生物功能的诊疗一体化AIEgens。本综述重点介绍了文献中AIEgens作为分子探针用于细菌、病毒和真菌的成像、鉴别及杀灭的实例。
