Moon Jung Hyeon, Cho Won-Sang, Kang Hyun-Seung, Kim Jeong Eun, Lee Seung Jin, Han Moon Hee
Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
J Korean Neurosurg Soc. 2011 Sep;50(3):191-4. doi: 10.3340/jkns.2011.50.3.191. Epub 2011 Sep 30.
The aim of this study was to analyze the treatment outcome of patients with vein of Galen aneurysmal malformations (VGM).
Clinical and angiographic data of six consecutive patients with VGM were retrospectively reviewed. VGMs were angiographically classified by Yasargil's method. Treatment outcomes were evaluated.
Mean age at initial treatment was 4.4±5.7 months. Angiographic types of VGMs were type II in two patients and type III in four. Three patients had cardiac symptoms and the others were asymptomatic. Two patients were treated with transvenous embolization, three with transarterial embolization, and one was managed conservatively. Two patients died due to venous hypertension few days after transvenous approach. Of three patients who were transarterially embolized, one was completely occluded with Onyx and two were incompletely occluded. During the follow-up period (range, one to six years) two of three patients treated with transarterial approach were asymptomatic and the other showed mild symptoms. One patient who was managed conservatively showed normal performance.
Transarterial embolization of VGMs may be better than transvenous approach in terms of the treatment outcome and complication. Further studies are needed because of the rarity of the disease and rapid advancement of endovascular techniques.
本研究旨在分析大脑大静脉动脉瘤样畸形(VGM)患者的治疗结果。
回顾性分析连续6例VGM患者的临床和血管造影资料。根据Yasargil方法对VGM进行血管造影分类,并评估治疗结果。
初次治疗时的平均年龄为4.4±5.7个月。VGM的血管造影类型为Ⅱ型2例,Ⅲ型4例。3例有心脏症状,其余无症状。2例行静脉栓塞治疗,3例行动脉栓塞治疗,1例保守治疗。2例在静脉入路后数天因静脉高压死亡。在3例行动脉栓塞治疗的患者中,1例使用Onyx完全闭塞,2例不完全闭塞。在随访期(1至6年)内,3例行动脉入路治疗的患者中有2例无症状,另1例有轻微症状。1例保守治疗的患者表现正常。
就治疗结果和并发症而言,VGM的动脉栓塞可能优于静脉入路。由于该疾病罕见且血管内技术发展迅速,还需要进一步研究。