Angiogenesis Laboratory, Institute for Biomedical Research, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Biochem Soc Trans. 2011 Dec;39(6):1606-11. doi: 10.1042/BST20110702.
RhoJ is an endothelially expressed member of the Cdc42 (cell division cycle 42) subfamily of small Rho GTPases. It is expressed in both the developing mammalian vasculature and the vascular beds of a number of adult tissues, with its expression regulated by the endothelial transcription factor ERG (ETS-related gene). RhoJ has been shown to regulate endothelial motility, tubulogenesis and lumen formation in vitro, and modulates the vascularization of Matrigel plugs in vivo. Both vascular endothelial growth factor and semaphorin 3E have been found to affect its activation. RhoJ has been shown to be a focal-adhesion-localized Rho GTPase which can modulate focal adhesion number, actomyosin contractility and activity of Cdc42 and Rac1. The present review discusses the biology of RhoJ with a focus on recent reports of its role in endothelial cells and angiogenesis.
RhoJ 是 Cdc42（细胞分裂周期 42）亚家族中小 Rho GTPase 的一种内皮细胞表达成员。它在发育中的哺乳动物脉管系统和许多成年组织的血管床中表达，其表达受内皮转录因子 ERG（ETS 相关基因）调节。RhoJ 已被证明可调节体外内皮细胞运动性、管状形成和管腔形成，并调节体内 Matrigel 塞的血管生成。已发现血管内皮生长因子和神经鞘蛋白 3E 会影响其激活。RhoJ 已被证明是一种黏着斑定位的 Rho GTPase，可调节黏着斑数量、肌动球蛋白收缩性以及 Cdc42 和 Rac1 的活性。本综述讨论了 RhoJ 的生物学特性，重点介绍了其在血管内皮细胞和血管生成中的作用的最新报道。
