新生儿重症监护病房环境应激对早产儿神经发育及其表观遗传学影响的研究进展
[Research advances in the effect of environmental stress in the neonatal intensive care unit on the neurodevelopment of preterm infants and its epigenetics].
作者信息
Yue Shao-Ting, Zhang Jun, Ma Deng-Hui
机构信息
Department of Nursing, Wuhan University School of Health Sciences, Wuhan 430071, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2019 Nov;21(11):1144-1147. doi: 10.7499/j.issn.1008-8830.2019.11.016.
Abstract
Adverse environmental stimulation in the neonatal intensive care unit (NICU) can affect neurodevelopment through epigenetic modification and thus has adverse effects on the long-term developmental outcome of preterm infants. Developmental care can reverse epigenetic changes in genes and promote neurodevelopment in preterm infants. This article reviews the influence of environmental stress in the NICU and developmental care on neurodevelopment in preterm infants, as well as related epigenetic effects, in order to provide a reference for epigenetic studies of preterm infants.
摘要
新生儿重症监护病房（NICU）中的不良环境刺激可通过表观遗传修饰影响神经发育，从而对早产儿的长期发育结局产生不利影响。发育照护可逆转基因的表观遗传变化，并促进早产儿的神经发育。本文综述了NICU中的环境应激和发育照护对早产儿神经发育的影响以及相关的表观遗传效应，以期为早产儿的表观遗传学研究提供参考。
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