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2
[Research progress in epigenetic studies on systemic sclerosis].系统性硬化症表观遗传学研究进展
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018 Dec 28;43(12):1369-1375. doi: 10.11817/j.issn.1672-7347.2018.12.014.
3
Epigenetic Programming by Maternal Behavior in the Human Infant.人类婴儿中母体行为的表观遗传编程
Pediatrics. 2018 Oct;142(4). doi: 10.1542/peds.2017-1890.
4
[A single-center study on the incidence and mortality of preterm infants from 2006 to 2016].[一项关于2006年至2016年早产儿发病率和死亡率的单中心研究]
Zhongguo Dang Dai Er Ke Za Zhi. 2018 May;20(5):368-372. doi: 10.7499/j.issn.1008-8830.2018.05.006.
5
Is Less Noise, Light and Parental/Caregiver Stress in the Neonatal Intensive Care Unit Better for Neonates?新生儿重症监护病房中较少的噪音、光线及父母/照顾者压力对新生儿更好吗？
Indian Pediatr. 2018 Jan 15;55(1):17-21.
6
From early stress to 12-month development in very preterm infants: Preliminary findings on epigenetic mechanisms and brain growth.极早产儿从早期应激到12个月发育：表观遗传机制与脑生长的初步研究结果
PLoS One. 2018 Jan 5;13(1):e0190602. doi: 10.1371/journal.pone.0190602. eCollection 2018.
7
Early Procedural Pain Is Associated with Regionally-Specific Alterations in Thalamic Development in Preterm Neonates.早期程序性疼痛与早产儿丘脑发育的区域性变化有关。
J Neurosci. 2018 Jan 24;38(4):878-886. doi: 10.1523/JNEUROSCI.0867-17.2017. Epub 2017 Dec 18.
8
Developmental care, neonatal behavior and postnatal maternal depressive symptomatology predict internalizing problems at 18 months for very preterm children.发育照护、新生儿行为和产后母亲抑郁症状可预测极早产儿18个月时的内化问题。
J Perinatol. 2018 Feb;38(2):191-195. doi: 10.1038/jp.2017.148. Epub 2017 Sep 21.
9
Preterm behavioral epigenetics: A systematic review.早产行为表观遗传学：系统评价。
Neurosci Biobehav Rev. 2018 Jan;84:262-271. doi: 10.1016/j.neubiorev.2017.08.020. Epub 2017 Sep 1.
10
Individualized Developmental Care in the NICU: A Concept Analysis.新生儿重症监护病房中的个体化发育护理：概念分析
Adv Neonatal Care. 2017 Jun;17(3):162-174. doi: 10.1097/ANC.0000000000000374.

新生儿重症监护病房环境应激对早产儿神经发育及其表观遗传学影响的研究进展

[Research advances in the effect of environmental stress in the neonatal intensive care unit on the neurodevelopment of preterm infants and its epigenetics].

作者信息

Yue Shao-Ting, Zhang Jun, Ma Deng-Hui

机构信息

Department of Nursing, Wuhan University School of Health Sciences, Wuhan 430071, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2019 Nov;21(11):1144-1147. doi: 10.7499/j.issn.1008-8830.2019.11.016.

DOI:10.7499/j.issn.1008-8830.2019.11.016
PMID:31753099
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7389294/
Abstract

Adverse environmental stimulation in the neonatal intensive care unit (NICU) can affect neurodevelopment through epigenetic modification and thus has adverse effects on the long-term developmental outcome of preterm infants. Developmental care can reverse epigenetic changes in genes and promote neurodevelopment in preterm infants. This article reviews the influence of environmental stress in the NICU and developmental care on neurodevelopment in preterm infants, as well as related epigenetic effects, in order to provide a reference for epigenetic studies of preterm infants.

摘要

新生儿重症监护病房（NICU）中的不良环境刺激可通过表观遗传修饰影响神经发育，从而对早产儿的长期发育结局产生不利影响。发育照护可逆转基因的表观遗传变化，并促进早产儿的神经发育。本文综述了NICU中的环境应激和发育照护对早产儿神经发育的影响以及相关的表观遗传效应，以期为早产儿的表观遗传学研究提供参考。