Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Biomed Environ Sci. 2011 Oct;24(5):475-82. doi: 10.3967/0895-3988.2011.05.004.
To determine whether smoking increases the risk for developing metabolic syndrome (MetS) in Chinese men.
A total of 693 men with no MetS at baseline were followed for 2.9-5.5 years. Subjects were divided into nonsmokers, ex-smokers, and current smokers according to baseline smoking status.
After adjusting for age, education level, alcohol intake, fasting plasma insulin, HOMA-IR index, and BMI at baseline and weight change, current smokers were dose-dependently associated with increased risk for developing new MetS compared with nonsmokers. The odds ratio (OR) was 2.131 (95% CI, 1.264, 3.592; P<0.01) for the NCEPIII definition or 3.083 (95% CI, 1.807, 5.295; P<0.01) for the JCDCG definition of MetS. Ex-smokers who had quit for ≥13 years significantly decreased the risk for developing new MetS defined by the JCDCG definition. Compared with nonsmokers, current smokers were significantly associated with increased incidence of hypertriglyceridemia and low HDL-C.
Smoking is a risk factor for developing MetS in Chinese men after adjusting for age, education level, alcohol intake, fasting plasma insulin, HOMA-IR, BMI, and weight change. This could be due to an increased incidence of dyslipidemia. Smoking cessation for >13 years decreased the risk for developing MetS defined by the JCDCG definition.
确定吸烟是否会增加中国男性患代谢综合征（MetS）的风险。
共有 693 名基线时无 MetS 的男性进行了 2.9-5.5 年的随访。根据基线吸烟状况，将受试者分为不吸烟者、戒烟者和当前吸烟者。
在校正年龄、教育程度、饮酒量、空腹血浆胰岛素、HOMA-IR 指数和基线及体重变化时的 BMI 后，与不吸烟者相比，当前吸烟者与发生新的 MetS 的风险呈剂量依赖性增加。与 NCEPIII 定义相比，当前吸烟者的比值比（OR）为 2.131（95%CI，1.264，3.592；P<0.01），与 JCDCG 定义的 MetS 的 OR 为 3.083（95%CI，1.807，5.295；P<0.01）。戒烟≥13 年的戒烟者显著降低了 JCDCG 定义的新发 MetS 的风险。与不吸烟者相比，当前吸烟者与高三酰甘油血症和低 HDL-C 的发生率增加显著相关。
在调整年龄、教育程度、饮酒量、空腹血浆胰岛素、HOMA-IR、BMI 和体重变化后，吸烟是中国男性发生 MetS 的危险因素。这可能是由于血脂异常发生率增加所致。戒烟>13 年可降低 JCDCG 定义的 MetS 的发病风险。
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