吸烟者与非吸烟者中肥胖与血清抵抗素水平的关系。
The relation of obesity with serum resistin levels in smoker and nonsmokers.
作者信息
Gürsoy Gül, Eşbah Onur, Kirnap Nazli Gülsoy, Cetiner Hacer, Acar Yaşar, Demirbaş Berrin, Oztürk Abidin, Kiliç Zuhal
机构信息
Associate Professor, Department of Internal Medicine, Ministry of Health, Ankara Education and Research Hospital, Ankara, Turkey.
出版信息
J Res Med Sci. 2012 Feb;17(2):119-22.
BACKGROUND
The demonstration that adipose tissue produces numerous cytokines increases interest of investigators in their role in the pathogenesis of obesity. Resistin is one of those cytokines. There are conflicing reports as cigarette smoking impairs insulin secretion, augments insulin resistance, or has no effect on glucose metabolism. In our study, we intended to examine the relationship of obesity with resistin levels in smokers and nonsmokers.
PATIENTS AND METHODS
The study included 52 male smokers and 34 age matched nonsmoker male control subjects. We classified smoker and nonsmoker groups according to their body mass index as BMI < 27 and ≥27. As well as making physical and anthropometric examinations, fasting plasma glucose and insulin, postprandial plasma glucose, lipid profile, and resistin levels were measured in all male subjects. We compared all parameters in smoker and nonsmokers either having BMI < 27 or ≥27.
RESULTS
In both BMI levels, resistin levels were higher in smoker groups than nonsmoker ones (P<0.01 all), we did not find any difference in other parameters.
CONCLUSION
in conclusion we may speculate that if someone smokes resistin levels increase.
背景
脂肪组织可产生多种细胞因子，这一发现引发了研究人员对其在肥胖发病机制中作用的兴趣。抵抗素就是其中一种细胞因子。关于吸烟对胰岛素分泌、胰岛素抵抗的影响，或对糖代谢有无作用，存在相互矛盾的报道。在我们的研究中，我们旨在探讨吸烟者和非吸烟者中肥胖与抵抗素水平之间的关系。
患者与方法
该研究纳入了52名男性吸烟者和34名年龄匹配的非吸烟男性对照者。我们根据体重指数将吸烟者和非吸烟者分为BMI < 27和≥27两组。除了进行体格检查和人体测量外，还测量了所有男性受试者的空腹血糖、胰岛素、餐后血糖、血脂谱和抵抗素水平。我们比较了BMI < 27或≥27的吸烟者和非吸烟者的所有参数。
结果
在两个BMI水平上，吸烟者组的抵抗素水平均高于非吸烟者组（均P<0.01），我们未发现其他参数有任何差异。
结论
总之，我们可以推测，如果一个人吸烟，抵抗素水平会升高。
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