Methodist DeBakey Cardiology Associates, Smith Tower, 6550 Fannin, Suite 1901, Houston, TX 77030, USA.
Heart Fail Clin. 2012 Jan;8(1):101-11. doi: 10.1016/j.hfc.2011.08.003. Epub 2011 Oct 22.
Oxidative stress represents a persistent imbalance between the production and the compensation of reactive oxygen species. Though predominantly found in advanced heart failure, the most frequent "at-risk" condition has been associated with underlying oxidative stress. It is therefore conceivable that timely detection and early intervention to reduce oxidative stress processes provide an opportunity to prevent disease progression to overt heart failure. This article reviews the current understanding of the current evidence of oxidative stress involvement in the pathophysiology of human heart failure and its potential therapeutic interventions in patients with Stage A and B heart failure.
氧化应激代表活性氧产生与补偿之间的持续失衡。尽管主要存在于晚期心力衰竭中，但最常见的“高危”情况与潜在的氧化应激有关。因此，可以想象，及时发现和早期干预以减少氧化应激过程，为预防疾病进展为明显心力衰竭提供了机会。本文综述了当前对氧化应激在人类心力衰竭病理生理学中的作用及其在 A 期和 B 期心力衰竭患者中的潜在治疗干预的理解。
