College of Animal Science and Technology, Henan University of Science and Technology, No.70, Tianjin Road, 471003, Luoyang, People's Republic of China.
Biol Trace Elem Res. 2012 Jun;146(3):354-9. doi: 10.1007/s12011-011-9268-6. Epub 2011 Nov 23.
Oxidative stress is thought to be involved in lead-induced toxicity. The aim of this study was to investigate the possible protective role of naringenin on lead-induced oxidative stress in the liver and kidney of rats. In the present investigation, lead acetate (500 mg Pb/L) was administered orally for 8 weeks to induce hepatotoxicity and nephrotoxicity. The levels of hepatic and renal markers such as alanine aminotransferase, aspartate aminotransferase, urea, uric acid, and creatinine were significantly (P < 0.05) increased following lead acetate administration. Lead-induced oxidative stress in liver and kidney tissue was indicated by a significant (P < 0.05) increase in the level of maleic dialdehyde and decreased levels of reduced glutathione, superoxide dismutase, catalase, and glutathione peroxidase. Naringenin markedly attenuated lead-induced biochemical alterations in serum, liver, and kidney tissues (P < 0.05). The present study suggests that naringenin shows antioxidant activity and plays a protective role against lead-induced oxidative damage in the liver and kidney of rats.
氧化应激被认为与铅诱导的毒性有关。本研究旨在探讨柚皮素对大鼠肝脏和肾脏铅诱导氧化应激的可能保护作用。在本研究中，醋酸铅（500mg Pb/L）经口给予 8 周以诱导肝毒性和肾毒性。肝、肾功能标志物如丙氨酸氨基转移酶、天冬氨酸氨基转移酶、尿素、尿酸和肌酐的水平在给予醋酸铅后显著升高（P<0.05）。肝、肾组织中铅诱导的氧化应激表现为丙二醛水平显著升高（P<0.05），还原型谷胱甘肽、超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶水平降低。柚皮素显著减轻了铅诱导的血清、肝脏和肾脏组织的生化改变（P<0.05）。本研究表明，柚皮素具有抗氧化活性，对大鼠肝脏和肾脏的铅诱导氧化损伤起保护作用。
