Ozkaya Ahmet, Sahin Zafer, Dag Uzeyir, Ozkaraca Mustafa
Department of Chemistry, Faculty of Science and Art, Adiyaman University, Adiyaman, 02040, Turkey.
Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Necmettin Erbakan University, Konya, 42040, Turkey.
J Biochem Mol Toxicol. 2016 May;30(5):243-8. doi: 10.1002/jbt.21785. Epub 2016 Mar 1.
Lead has several adverse effects on the body due to one of the environmental pollutants. We aimed to determine the effects of naringenin on the oxidative stress and the hepatic damage against lead acetate treatment in the liver of male rats. Naringenin was administered by orogastric gavage (50 mg/kg) and lead acetate was given as daily 500 parts per million in drinking water for 4 weeks. Lead and antioxidant activities were measured, and histopathological evaluation was performed in the liver. Lead concentrations, malondialdehyde, and antioxidant activity were restored by the naringenin. The grade of necrosis, hydropic degeneration, and hepatic cord disorganization was decreased by the naringenin. However, there were no differences in the degree of sinusoidal congestion, hepatic steatosis, and capsular fibrosis between lead acetate and naringenin + lead acetate groups. We can suggest that naringenin has antioxidant and chelating effects in the liver. Nevertheless, this effect is not enough against the lead acetate induced hepatic injury.
铅作为环境污染物之一，会对人体产生多种不良影响。我们旨在确定柚皮素对雄性大鼠肝脏氧化应激以及醋酸铅处理所致肝脏损伤的影响。通过经口灌胃给予柚皮素（50毫克/千克），并在饮水中每日给予百万分之500的醋酸铅，持续4周。测定肝脏中的铅含量和抗氧化活性，并进行组织病理学评估。柚皮素可使铅浓度、丙二醛和抗氧化活性恢复正常。柚皮素可降低坏死程度、水样变性和肝索紊乱程度。然而，醋酸铅组与柚皮素+醋酸铅组之间在窦状隙充血、肝脂肪变性和包膜纤维化程度上并无差异。我们可以认为柚皮素在肝脏中具有抗氧化和螯合作用。然而，这种作用对于醋酸铅诱导的肝损伤来说并不足够。
