IdiPAZ Health Research Institute, Spain.
Cephalalgia. 2011 Dec;31(16):1609-17. doi: 10.1177/0333102411427599. Epub 2011 Nov 22.
Whether migraine is associated with a higher prevalence of hypercoagulable states (HS) in ischemic stroke patients is unknown.
This was a prospective study of patients under 55 years of age with brain ischemia. A systematic questionnaire addressed the antecedent of migraine with aura (MA) or without aura (MO). We investigated the presence of HS by an extensive battery of haematological tests. The presence of patent foramen ovale (PFO) was assessed by trans-oesophageal echocardiography.
A total of 154 patients (95 men; mean ± SD age, 44.12 ± 8.4 years) were included; 44 had migraine, 15 had MA. HS were more frequent in the migraine than non-migraine group (38.6% vs. 16.4%, p < 0.01). The multivariate analysis showed that MO was associated with a 2.88-fold (95% CI, 1.14 to 7.28) increased risk of HS diagnosis. However, in the group of patients with brain infarction under 50 years old, MA, but not MO, was independently associated with HS (OR 6.81; 95% CI, 1.01 to 45.79).
In young patients with ischemic stroke, migraine may be associated with a higher frequency of HS.
偏头痛是否与缺血性脑卒中患者中更高的高凝状态（HS）发生率有关尚不清楚。
这是一项对 55 岁以下脑缺血患者的前瞻性研究。系统问卷询问有先兆偏头痛（MA）或无先兆偏头痛（MO）的病史。我们通过广泛的血液学测试来研究 HS 的存在。通过经食管超声心动图评估卵圆孔未闭（PFO）的存在。
共纳入 154 例患者（95 例男性；平均年龄 44.12 ± 8.4 岁）；44 例偏头痛，15 例 MA。偏头痛组 HS 发生率高于非偏头痛组（38.6% vs. 16.4%，p < 0.01）。多变量分析显示，MO 与 HS 诊断的风险增加 2.88 倍（95% CI，1.14 至 7.28）相关。然而，在年龄小于 50 岁的脑梗死患者中，MA 而非 MO 与 HS 独立相关（OR 6.81；95% CI，1.01 至 45.79）。
在年轻的缺血性脑卒中患者中，偏头痛可能与更高的 HS 发生率相关。
