Holopigian K, Seiple W, Mayron C, Koty R, Lorenzo M
Department of Ophthalmology, New York University Medical Center, New York 10016.
Invest Ophthalmol Vis Sci. 1990 Sep;31(9):1863-8.
Temporal sensitivity was assessed in patients with primary open-angle glaucoma (POAG) and ocular hypertension (OHT). Three measures of flicker sensitivity were obtained: psychophysical modulation thresholds, visual-evoked potentials (VEPs), and focal electroretinograms (FERGs). We found elevated psychophysical thresholds at higher temporal frequencies (30-50 Hz) in patients with POAG, relative to thresholds for age-matched controls. The OHT patients had elevated psychophysical thresholds only at 50 Hz. On the other hand, VEP amplitudes in POAG patients were reduced at all temporal frequencies, with the magnitude of the loss increasing with temporal frequency. The OHT patients, however, showed no reductions in VEP amplitude at any temporal frequency. Finally, POAG patients' FERG amplitudes were reduced at 30-50 Hz; whereas FERG amplitudes in the OHT patients were normal at all temporal frequencies. These results indicate that OHT patients can exhibit psychophysical threshold losses at high temporal frequencies which are not observed in the suprathreshold electrophysiological amplitude measures. On the other hand, patients with POAG show both psychophysical and VEP losses across a range of temporal frequencies. In addition, the decreases in FERG amplitudes in POAG patients suggest changes in the functioning of the outer retina in this disease.
对原发性开角型青光眼（POAG）和高眼压症（OHT）患者进行了时间敏感性评估。获得了三种闪烁敏感性测量指标：心理物理调制阈值、视觉诱发电位（VEP）和局灶性视网膜电图（FERG）。我们发现，与年龄匹配的对照组相比，POAG患者在较高时间频率（30 - 50Hz）下的心理物理阈值升高。OHT患者仅在50Hz时心理物理阈值升高。另一方面，POAG患者在所有时间频率下VEP振幅均降低，且损失幅度随时间频率增加。然而，OHT患者在任何时间频率下VEP振幅均未降低。最后，POAG患者在30 - 50Hz时FERG振幅降低；而OHT患者在所有时间频率下FERG振幅均正常。这些结果表明，OHT患者在高时间频率下可出现心理物理阈值损失，而上阈值电生理振幅测量中未观察到这种情况。另一方面，POAG患者在一系列时间频率下均表现出心理物理和VEP损失。此外，POAG患者FERG振幅降低表明该疾病中外层视网膜功能发生了变化。
