Parisi V, Bucci M G
Istituto di Clinica Oculistica-Università di Roma Tor Vergata, Italy.
Invest Ophthalmol Vis Sci. 1992 Feb;33(2):436-42.
Visual evoked potentials (VEPs) were assessed in basal condition and after photostress in normal subjects, in subjects with ocular hypertension (OHT), and in subjects with primary open-angle glaucoma (POAG). The VEPs recorded in basal condition showed that in patients with OHT and POAG a latency of the P100 peak was higher than in controls. The amplitudes were reduced in POAG patients but not in OHT patients. In all eyes, the VEPs recorded 20 s after photostress showed an increase in latency and a decrease in amplitude. In the control eyes, the functional recovery was complete after 80 s. In the eyes with OHP and in the eyes with POAG, the parameters of VEP after photostress underwent greater changes than in the control eyes. VEPs were superimposable on the basal condition (recovery time) at 73.2 s in OHT patients and at 113.2 s in POAG patients. The longer VEP recovery time after photostress observed in OHT and POAG patients could be attributed to the reduced functionality of the outer layers or the inner retinal layers of the central retina, or both. This test may be useful in the clinical evaluation for early diagnosis of glaucoma.
在正常受试者、高眼压症（OHT）患者和原发性开角型青光眼（POAG）患者中，于基础状态和光应激后评估视觉诱发电位（VEP）。基础状态下记录的VEP显示，OHT和POAG患者的P100峰潜伏期高于对照组。POAG患者的波幅降低，但OHT患者的波幅未降低。在所有眼睛中，光应激后20秒记录的VEP显示潜伏期延长和波幅降低。在对照眼中，80秒后功能完全恢复。在OHT眼和POAG眼中，光应激后VEP的参数变化比对照眼更大。OHT患者在73.2秒时VEP可叠加至基础状态（恢复时间），POAG患者在113.2秒时可叠加。在OHT和POAG患者中观察到的光应激后VEP恢复时间延长，可能归因于中央视网膜外层或内层视网膜层功能降低，或两者均降低。该测试可能有助于青光眼早期诊断的临床评估。
