Murai Hideki, Suzuki Yukihisa, Kiyosawa Motohiro, Wakakura Masato, Mochizuki Manabu, Ishiwata Kiichi, Ishii Kenji
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Graduate School, Tokyo, Japan.
Case Rep Ophthalmol. 2011 Jan;2(1):50-4. doi: 10.1159/000324459. Epub 2011 Feb 5.
A 43-year-old woman with drug-related blepharospasm was followed up for 22 months. She had undergone etizolam treatment for 19 years for indefinite complaints. We examined her cerebral glucose metabolism 5 times (between days 149 and 688 since presentation), using positron emission tomography, and identified regions of interest in the thalamus, caudate nucleus, putamen, and primary somatosensory area on both sides. The severity of the blepharospasm was evaluated by PET scanning using the Wakakura classification. Sixteen women (mean age 42.4 ± 11.7 years) were examined as normal controls. The thalamic glucose metabolism in our patient was significantly increased on days 149, 212, and 688. The severity of the blepharospasm was positively correlated with the thalamic glucose metabolism, suggesting that the severity of blepharospasms reflects thalamic activity.
一名患有药物相关性眼睑痉挛的43岁女性接受了22个月的随访。她因不明原因的不适接受了19年的艾司唑仑治疗。我们使用正电子发射断层扫描对她的脑葡萄糖代谢进行了5次检查（自就诊以来的第149天至688天之间），并在双侧丘脑、尾状核、壳核和初级体感区确定了感兴趣区域。使用若仓分类法通过PET扫描评估眼睑痉挛的严重程度。16名女性（平均年龄42.4±11.7岁）作为正常对照接受了检查。我们的患者在第149天、212天和688天丘脑葡萄糖代谢显著增加。眼睑痉挛的严重程度与丘脑葡萄糖代谢呈正相关，表明眼睑痉挛的严重程度反映了丘脑活动。
