Young A B, Penney J B, Starosta-Rubinstein S, Markel D S, Berent S, Giordani B, Ehrenkaufer R, Jewett D, Hichwa R
Ann Neurol. 1986 Sep;20(3):296-303. doi: 10.1002/ana.410200305.
Fifteen drug-free patients with early to midstage Huntington's disease were evaluated with quantitative neurological examinations, scales for functional capacity, computed tomographic (CT) scans, and positron emission tomographic (PET) scans of 18F-2-fluoro-2-deoxyglucose (18F-FDG) uptake. All patients had abnormal indices of caudate metabolism on PET scanning, whereas in patients with early disease indices of putamen metabolism and CT measures of caudate atrophy were normal. Indices of caudate metabolism correlated highly with the patients' overall functional capacity (r = 0.906; p less than 0.001) and bradykinesia/rigidity (r = -0.692; p less than 0.01). Indices of putamen metabolism correlated highly with motor functions: chorea (r = -0.841; p less than 0.01), oculomotor abnormalities (r = -0.849; p less than 0.01), and fine motor coordination (r = -0.866; p less than 0.01). Indices of thalamic metabolism correlated positively with dystonia (r = 0.559; p less than 0.05). The data suggest that PET scanning with 18F-FDG is a sensitive measure of brain dysfunction in Huntington's disease and that basal ganglia metabolism is highly correlated with the overall functional capacity of individual patients and with the degree of their motor abnormalities.
对15名处于亨廷顿病早期至中期且未服用药物的患者进行了定量神经学检查、功能能力量表评估、计算机断层扫描（CT）以及18F-2-氟-2-脱氧葡萄糖（18F-FDG）摄取的正电子发射断层扫描（PET）。所有患者的PET扫描显示尾状核代谢指标异常，而早期疾病患者的壳核代谢指标及尾状核萎缩的CT测量结果均正常。尾状核代谢指标与患者的整体功能能力高度相关（r = 0.906；p < 0.001）以及运动迟缓/僵硬（r = -0.692；p < 0.01）。壳核代谢指标与运动功能高度相关：舞蹈症（r = -0.841；p < 0.01）、动眼神经异常（r = -0.849；p < 0.01）以及精细运动协调（r = -0.866；p < 0.01）。丘脑代谢指标与肌张力障碍呈正相关（r = 0.559；p < 0.05）。数据表明，18F-FDG的PET扫描是亨廷顿病脑功能障碍的敏感测量方法，并且基底神经节代谢与个体患者的整体功能能力及其运动异常程度高度相关。
