Fenstermacher M J, Narayana P A
University of Texas Medical School, Department of Radiology, Houston 77030.
Invest Radiol. 1990 Sep;25(9):1034-9. doi: 10.1097/00004424-199009000-00016.
Four patients were observed serially with 1H magnetic resonance spectroscopy (MRS) at times ranging from 3 days to 10 weeks after a documented ischemic event. Spectra were obtained from 8 cc volumes in infarcted regions and contralateral matched normal regions. Reproducible variations in n-acetyl aspartate (NAA), creatine + phosphocreatine (Cr + PCr), and the sequential changes in lactate and lipid resonances are related to the pathophysiology of stroke. A conspicuous lack of significant change in the choline (Cho) resonance with concomitant decrease in NAA and Cr + PCr is reported as a possible marker of ischemic injury.
对4例患者在记录到缺血事件后的3天至10周内，连续进行了氢质子磁共振波谱（MRS）观察。从梗死区域和对侧匹配的正常区域的8立方厘米体积中获取波谱。N-乙酰天门冬氨酸（NAA）、肌酸+磷酸肌酸（Cr+PCr）的可重复性变化，以及乳酸和脂质共振的序列变化与中风的病理生理学相关。据报道，胆碱（Cho）共振明显缺乏显著变化，同时NAA和Cr+PCr减少，这可能是缺血性损伤的一个标志物。
