头孢曲松诱导的胆汁假性结石形成是否受尿苷二磷酸葡萄糖醛酸基转移酶1A1基因多态性的影响？
Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?
作者信息
Fretzayas Andrew, Liapi Olga, Papadopoulou Anna, Nicolaidou Polyxeni, Stamoulakatou Alexandra
机构信息
Third Department of Pediatrics, "Attikon" General University Hospital, 1 Rimini Street, Haidari, 124 62 Athens, Greece.
出版信息
Case Rep Med. 2011;2011:730250. doi: 10.1155/2011/730250. Epub 2011 Oct 26.
Ceftriaxone (cfx), a third-generation cephalosporin antibiotic, leads to transient cholelithiasis in some children, also known as pseudolithiasis. However, the underlying pathogenetic mechanism of this adverse effect has not yet been elucidated. We describe 3 children with ceftriaxone-induced pseudolithiasis, who were also carriers of the A(TA)(7)TAA polymorphism of the UGT1A1 gene, implying that a cause and effect relation may exist.
头孢曲松（cfx）是一种第三代头孢菌素抗生素，在一些儿童中会导致短暂性胆石症，也称为假性胆石症。然而，这种不良反应的潜在发病机制尚未阐明。我们描述了3例头孢曲松诱导的假性胆石症患儿，他们也是UGT1A1基因A(TA)(7)TAA多态性的携带者，这意味着可能存在因果关系。
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