Miyazawa T, Sho C, Nakagawa H, Oshino N
Nihon Schering K.K., Research Department, Osaka, Japan.
Invest Radiol. 1990 Sep;25(9):999-1003. doi: 10.1097/00004424-199009000-00008.
Aspiration is a serious complication of oral contrast media (CM). The authors investigated the effects of iotrolan, iopamidol, and diatrizoate in rats' lungs. To quantify the lung damage induced by CM, pulmonary water and hemoglobin contents were determined. Arterial blood-gas exchange (pH, PCO2, and PO2) also was determined as an indicator of respiratory function. Iotrolan, iopamidol, or sodium/meglumine diatrizoate with a concentration of 300 mg I/mL was administered intrabronchially at a dose of 1 mL/kg. Physiologic saline was administered to the control group. Ten minutes after administration, arterial blood was collected and the lung was removed. Diatrizoate and iopamidol increased pulmonary water and hemoglobin contents and decreased blood PO2. The effect of iotrolan on these parameters was slight and no significant differences were observed between the iotrolan and saline groups. These results suggest that iotrolan is a preferable CM for gastrointestinal examination in the case of suspected aspiration.
误吸是口服造影剂（CM）的一种严重并发症。作者研究了碘曲仑、碘帕醇和泛影酸盐对大鼠肺部的影响。为了量化由CM引起的肺损伤，测定了肺含水量和血红蛋白含量。还测定了动脉血气交换（pH、PCO2和PO2）作为呼吸功能的指标。将浓度为300mg I/mL的碘曲仑、碘帕醇或钠/葡甲胺泛影酸盐以1mL/kg的剂量经支气管给药。对照组给予生理盐水。给药10分钟后，采集动脉血并取出肺脏。泛影酸盐和碘帕醇增加了肺含水量和血红蛋白含量，并降低了血氧分压。碘曲仑对这些参数的影响较小，碘曲仑组和生理盐水组之间未观察到显著差异。这些结果表明，在怀疑有误吸的情况下，碘曲仑是胃肠道检查中更可取的造影剂。
