Miyazawa T, Nakagawa H
Biological Research Group, Nihon Schering K.K.
Nihon Igaku Hoshasen Gakkai Zasshi. 1990 Nov 25;50(11):1381-6.
Authors evaluated the efficacy and tolerability of iotrolan, a nonionic dimeric contrast medium used for myelography, as an arthrographic contrast medium in comparison with meglumine/sodium diatrizoate and iopamidol in rabbit. Iotrolan (Isovist, 300 mgI/ml) was injected in one knee joint and diatrizoate (Urografin, 292 mgI/ml) or iopamidol (Iopamiron, 300 mgI/ml) in the other at a dose of 1.5 ml/knee. Knee arthrograms were taken 2, 5, 10, 20, 30, 45 and 60 min after injection. Contrast density was determined by measuring the transmission density in the supra-patellar bursa with an image analysis system. The anterior displacement of the patellar from the femur was measured as an indicator of hydrarthrosis. Contrast duration in the supra-patellar bursa was longer with iotrolan than with diatrizoate and iopamidol. Hydrarthrosis was less pronounced with iotrolan than with diatrizoate and iopamidol. These results suggest that iotrolan has the advantage over existing contrast media for arthrography with respect to the efficacy and tolerability.
作者评估了碘曲仑（一种用于脊髓造影的非离子二聚体造影剂）作为关节造影剂与葡甲胺/泛影酸钠和碘帕醇相比在兔体内的有效性和耐受性。将碘曲仑（伊索显，300mgI/ml）注入一个膝关节，将泛影酸盐（优维显，292mgI/ml）或碘帕醇（碘必乐，300mgI/ml）以1.5ml/膝关节的剂量注入另一个膝关节。在注射后2、5、10、20、30、45和60分钟拍摄膝关节造影。通过使用图像分析系统测量髌上囊的透射密度来确定造影剂密度。测量髌骨相对于股骨的前移作为关节积液的指标。碘曲仑在髌上囊中的造影剂持续时间比泛影酸盐和碘帕醇更长。碘曲仑引起的关节积液比泛影酸盐和碘帕醇更不明显。这些结果表明，在有效性和耐受性方面，碘曲仑在关节造影方面优于现有造影剂。
