Martinez-Lavin Manuel
Rheumatology Department, National Institute of Cardiology, Juan Badiano 1, 14080 Mexico City, DF, Mexico.
Pain Res Treat. 2012;2012:981565. doi: 10.1155/2012/981565. Epub 2011 Sep 19.
Fibromyalgia is a painful stress-related disorder. A key issue in fibromyalgia research is to investigate how distress could be converted into pain. The sympathetic nervous system is the main element of the stress response system. In animal models, physical trauma, infection, or distressing noise can induce abnormal connections between the sympathetic nervous system and the nociceptive system. Dorsal root ganglia sodium channels facilitate this type of sympathetic pain. Similar mechanisms may operate in fibromyalgia. Signs of sympathetic hyperactivity have been described in this condition. Genetic factors and/or distressful lifestyle may lead to this state of sympathetic hyperactivity. Trauma and infection are recognized fibromyalgia triggers. Women who suffer from fibromyalgia have catecholamine-evoked pain. Sympathetic dysfunction may also explain nonpain-related fibromyalgia symptoms. In conclusion, in fibromyalgia, distress could be converted into pain through forced hyperactivity of the sympathetic component of the stress response system.
纤维肌痛是一种与压力相关的疼痛性疾病。纤维肌痛研究中的一个关键问题是探究困扰如何转化为疼痛。交感神经系统是应激反应系统的主要组成部分。在动物模型中，身体创伤、感染或令人痛苦的噪音可诱发交感神经系统与伤害感受系统之间的异常连接。背根神经节钠通道促进了这种类型的交感神经痛。类似的机制可能在纤维肌痛中起作用。在这种疾病中已描述了交感神经过度活跃的迹象。遗传因素和/或痛苦的生活方式可能导致这种交感神经过度活跃的状态。创伤和感染是公认的纤维肌痛触发因素。患有纤维肌痛的女性会出现儿茶酚胺诱发的疼痛。交感神经功能障碍也可能解释与疼痛无关的纤维肌痛症状。总之，在纤维肌痛中，困扰可能通过应激反应系统交感神经部分的强迫性过度活跃转化为疼痛。
