Kilic Şahhan, Asal Süha, Babaoğlu Mert, Yavuz Samet, Bilehsavar Mohaddeseh Davoudi, Altınışık Hatice, Gül Yusuf Turan, Oğuz Mustafa, Doğan Selami, Orhan Ahmet Lütfullah
Department of Cardiology, Çorlu State Hospital, Tekirdağ, Türkiye.
Department of Cardiology, Health Sciences University Sultan 2, Abdülhamid Han Training and Research Hospital, Tekirdağ, Türkiye.
Biomark Med. 2025 Apr;19(8):295-304. doi: 10.1080/17520363.2025.2483158. Epub 2025 Mar 24.
This study evaluates the association between the Intermountain Risk Score (IMRS) and coronary artery ectasia (CAE) to determine its predictive value.
MATERIALS & METHODS: A retrospective study was conducted at a tertiary hospital from January 2019 to January 2024. A total of 446 patients (226 with CAE, 220 controls) were included. Clinical, laboratory, and angiographic data were analyzed. IMRS was calculated based on routine demographic and laboratory parameters. Statistical analyses included logistic regression and receiver operating characteristic (ROC) curve analysis.
Patients with CAE had significantly higher IMRS scores ( = 0.011) and were more likely to fall into high-risk IMRS categories ( = 0.002). Smoking (HR: 3.744, = 0.045), mean corpuscular volume (HR: 1.105, = 0.019), and IMRS color category (HR: 5.255, = 0.016) were independent predictors. ROC analysis showed an AUC of 0.617 for IMRS score and 0.627 for IMRS color category.
IMRS is a significant predictor of CAE and may serve as a practical risk stratification tool. Higher-risk patients could benefit from closer monitoring and targeted interventions. Further validation in prospective studies is needed.
本研究评估山间风险评分(IMRS)与冠状动脉扩张(CAE)之间的关联,以确定其预测价值。
于2019年1月至2024年1月在一家三级医院进行了一项回顾性研究。共纳入446例患者(226例CAE患者,220例对照)。分析了临床、实验室和血管造影数据。IMRS基于常规人口统计学和实验室参数进行计算。统计分析包括逻辑回归和受试者工作特征(ROC)曲线分析。
CAE患者的IMRS评分显著更高(=0.011),且更有可能属于高风险IMRS类别(=0.002)。吸烟(HR:3.744,=0.045)、平均红细胞体积(HR:1.105,=0.019)和IMRS颜色类别(HR:5.255,=0.016)是独立预测因素。ROC分析显示IMRS评分的AUC为0.617,IMRS颜色类别的AUC为0.627。
IMRS是CAE的重要预测因素,可作为一种实用的风险分层工具。高风险患者可能受益于更密切的监测和针对性干预。需要在前瞻性研究中进一步验证。