National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Level 2, 376 Victoria St, Darlinghurst, NSW 2010, Australia.
Expert Rev Clin Pharmacol. 2009 Jul;2(4):381-90. doi: 10.1586/ecp.09.11.
Metabolic disturbances associated with HIV disease have become an important factor in patient management and have important implications for long-term outcomes, both in regards to mortality and healthcare burden. Recent research has implicated both HIV infection itself and specific antiretroviral therapies in the development of these disorders. This review examines recent findings from research into insulin and glucose dysregulation, serum lipid abnormalities, adipose tissue and derangements in bone metabolism. This review then describes the cardiovascular consequences and management of these metabolic disorders, and summarizes current thinking on the pathogenesis and effects of antiretroviral therapy. Finally, the review raises some questions regarding ongoing challenges and unmet needs in this field of research.
与 HIV 疾病相关的代谢紊乱已成为患者管理的一个重要因素，对长期结果（包括死亡率和医疗保健负担）具有重要意义。最近的研究表明，HIV 感染本身和特定的抗逆转录病毒疗法都会导致这些疾病的发生。本综述检查了胰岛素和葡萄糖失调、血清脂质异常、脂肪组织和骨代谢紊乱的最新研究结果。然后，本文描述了这些代谢紊乱的心血管后果和管理，并总结了目前对发病机制和抗逆转录病毒治疗效果的思考。最后，本文提出了一些关于该研究领域持续挑战和未满足需求的问题。
