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肠病相关T细胞淋巴瘤:一项诊断挑战

[Enteropathy-associated T-cell lymphoma: a diagnostic challenge].

作者信息

Busto Bea Victoria, Crespo Pérez Laura, Rodríguez-Gandía Miguel Ángel, Roy Ariño Garbiñe, García-Miralles Noemí, Cano Ruiz Ana

机构信息

Servicio de Aparato Digestivo, Hospital Universitario Ramón y Cajal, Madrid, España.

出版信息

Gastroenterol Hepatol. 2011 Dec;34(10):686-9. doi: 10.1016/j.gastrohep.2011.08.004. Epub 2011 Nov 22.

Abstract

Diagnosis of refractory celiac disease (CD) is based on exclusion of other disorders, persistence of malabsorptive symptoms and villous atrophy, despite a strict gluten-free diet for at least 6-12 months. Detection of alterations in the intraepithelial lymphocyte population is crucial for diagnosis. A subgroup of patients with refractory CD may develop severe complications such as enteropathy-associated T cell lymphoma (EATL). We present the case of a patient with longstanding silent CD who developed EALT, highlighting the challenge posed by the diagnosis and treatment of this entity.

摘要

难治性乳糜泻(CD)的诊断基于排除其他疾病,尽管严格遵循无麸质饮食至少6 - 12个月,但吸收不良症状和绒毛萎缩仍然持续存在。检测上皮内淋巴细胞群的改变对诊断至关重要。难治性CD患者的一个亚组可能会发生严重并发症,如肠病相关T细胞淋巴瘤(EATL)。我们报告了一例长期无症状CD患者发生EALT的病例,突出了该疾病诊断和治疗所带来的挑战。

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