与逆转录病毒感染相关的肿瘤发生

Tumorigenesis related to retroviral infections.

作者信息

Braoudaki Maria, Tzortzatou-Stathopoulou Fotini

机构信息

University Research Institute for the Study and Treatment of Childhood Genetic and Malignant Diseases, University of Athens, Aghia Sophia Children's Hospital, Athens, Greece.

出版信息

J Infect Dev Ctries. 2011 Nov 15;5(11):751-8. doi: 10.3855/jidc.1773.

DOI:10.3855/jidc.1773

PMID:22112727

Abstract

Retroviral infections are considered important risk factors for cancer development in humans since approximately 15-20% of cancer worldwide is caused by an infectious agent. This report discusses the most established oncogenic retroviruses, including human immunodeficiency virus (HIV), human T-cell leukemia virus (HTLV-1 and -2), Rous sarcoma virus (RSV), Abelson murine leukemia virus (A-MuLV), Moloney murine leukemia virus (M-MuLV), murine mammary tumor virus (MMTV), bovine leukemia virus, (BLV), Jaagsiekte sheep retrovirus (JSRV), and Friend spleen focus-forming virus (SFFV). The role of retroviruses as inducers of carcinogenesis, the mechanisms underlying oncogenic transformation, and the routes of transmission of several cancer-related retroviral infections are also described. Finally, the impact of cancer-related retroviral infections in the developing world is addressed. This review is an update of carcinogenesis caused by retroviral infections.

摘要

逆转录病毒感染被认为是人类癌症发展的重要风险因素，因为全球约15%-20%的癌症是由感染因子引起的。本报告讨论了最著名的致癌逆转录病毒，包括人类免疫缺陷病毒（HIV）、人类T细胞白血病病毒（HTLV-1和-2）、劳氏肉瘤病毒（RSV）、阿贝尔逊鼠白血病病毒（A-MuLV）、莫洛尼鼠白血病病毒（M-MuLV）、鼠乳腺肿瘤病毒（MMTV）、牛白血病病毒（BLV）、绵羊肺腺瘤病毒（JSRV）和弗瑞德脾集落形成病毒（SFFV）。还描述了逆转录病毒作为致癌诱导剂的作用、致癌转化的潜在机制以及几种与癌症相关的逆转录病毒感染的传播途径。最后，探讨了与癌症相关的逆转录病毒感染在发展中世界的影响。本综述是对逆转录病毒感染致癌作用的更新。