LABORGANICS, Department of Chemistry, Federal University of Sergipe, 49100-000, São Cristóvão, SE, Brazil.
Molecules. 2011 Nov 23;16(11):9714-20. doi: 10.3390/molecules16119714.
Phytochemical investigation of the branches of Annona foetida Mart. led to isolation from the CH(2)Cl(2) extract of four alkaloids: Atherospermidine (1), described for the first time in this species, liriodenine (2), O-methylmoschatoline (3), and annomontine (4). Their chemical structures were established on the basis of spectroscopic data from IR, MS, NMR (1D and 2D), and comparison with the literature. Compounds 2-4 showed potent trypanocidal effect when evaluated against epimastigote and trypomastigote forms of Trypanosoma cruzi.
从番荔枝科番荔枝属植物番荔枝的枝部分离得到 4 个生物碱：阿罗司帕定（1）、利罗定（2）、O-甲基毛果芸香碱（3）和番荔枝宁（4）。这是首次在该种植物中发现阿罗司帕定。根据红外光谱（IR）、质谱（MS）、核磁共振（1D 和 2D）等光谱数据并与文献进行比较，确定了它们的化学结构。化合物 2-4 对克氏锥虫的滋养体和鞭毛体形式具有很强的杀锥虫作用。
