产紫假单胞菌产生的新型肽内酯抗生素——詹氏菌素A、B和C。I. 分类学、发酵、分离、理化性质及生物学特性
Janthinocins A, B and C, novel peptide lactone antibiotics produced by Janthinobacterium lividum. I. Taxonomy, fermentation, isolation, physico-chemical and biological characterization.
作者信息
O'Sullivan J, McCullough J, Johnson J H, Bonner D P, Clark J C, Dean L, Trejo W H
机构信息
Squibb Institute for Medical Research, Princeton, NJ 08543-4000.
出版信息
J Antibiot (Tokyo). 1990 Aug;43(8):913-9. doi: 10.7164/antibiotics.43.913.
Janthinocins A, B and C are novel antibacterial agents produced by Janthinobacterium lividum. They were isolated from fermentation broths and characterized by UV, IR, NMR and mass spectroscopy. They are cyclic decapeptide lactones with marked activity against aerobic and anaerobic Gram-positive bacteria and are 2 to 4 times more potent in vitro than vancomycin. Janthinocins A and B were also found to be effective in a Staphylococcus aureus systemic infection in mice.
紫色杆菌素A、B和C是由紫色杆菌产生的新型抗菌剂。它们从发酵液中分离出来，并通过紫外光谱、红外光谱、核磁共振和质谱进行表征。它们是环状十肽内酯，对需氧和厌氧革兰氏阳性菌具有显著活性，体外活性比万古霉素强2至4倍。紫色杆菌素A和B在小鼠金黄色葡萄球菌全身感染中也被发现有效。
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