旋覆花醌A，一种可竞争特异性[3H]伊维菌素结合位点的杀线虫剂。
Cochlioquinone A, a nematocidal agent which competes for specific [3H]ivermectin binding sites.
作者信息
Schaeffer J M, Frazier E G, Bergstrom A R, Williamson J M, Liesch J M, Goetz M A
机构信息
Department of Biochemical Parasitology, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065.
出版信息
J Antibiot (Tokyo). 1990 Sep;43(9):1179-82. doi: 10.7164/antibiotics.43.1179.
PMID:2211380
Abstract
Cochlioquinone A, isolated from the fungus Helminthosporium sativum, was found to have nematocidal activity. Cochlioquinone A is a competitive inhibitor of specific [3H]ivermectin binding suggesting that cochlioquinone A and ivermectin interact with the same membrane receptor.
摘要
从真菌稻瘟病菌中分离出的辅酶Q A被发现具有杀线虫活性。辅酶Q A是特异性[3H]伊维菌素结合的竞争性抑制剂，这表明辅酶Q A和伊维菌素与同一膜受体相互作用。
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