Degenkolb Thomas, Vilcinskas Andreas
Institute for Insect Biotechnology, Justus-Liebig-University of Giessen, Heinrich-Buff-Ring 26-32, D-35392, Giessen, Germany.
Department of Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology, Winchester Strasse 2, D-35394, Giessen, Germany.
Appl Microbiol Biotechnol. 2016 May;100(9):3813-24. doi: 10.1007/s00253-015-7234-5. Epub 2016 Jan 4.
In this second section of a two-part mini-review article, we introduce 101 further nematicidal and non-nematicidal secondary metabolites biosynthesized by nematophagous basidiomycetes or non-nematophagous ascomycetes and basidiomycetes. Several of these compounds have promising nematicidal activity and deserve further and more detailed analysis. Thermolides A and B, omphalotins, ophiobolins, bursaphelocides A and B, illinitone A, pseudohalonectrins A and B, dichomitin B, and caryopsomycins A-C are excellent candidates or lead compounds for the development of biocontrol strategies for phytopathogenic nematodes. Paraherquamides, clonostachydiol, and nafuredins offer promising leads for the development of formulations against the intestinal nematodes of ruminants.
在这篇分为两部分的小型综述文章的第二部分中,我们介绍了另外101种由捕食线虫的担子菌或非捕食线虫的子囊菌和担子菌生物合成的杀线虫和非杀线虫次生代谢产物。其中几种化合物具有良好的杀线虫活性,值得进一步更详细的分析。热内酯A和B、脐孢菌素、蛇孢菌素、松材线虫素A和B、伊利尼酮A、假卤甲菌素A和B、二色菌素B以及颖壳霉素A - C是开发植物病原线虫生物防治策略的优秀候选物或先导化合物。对映海葵酰胺、枝顶孢二醇和萘呋菌素为开发针对反刍动物肠道线虫的制剂提供了有前景的线索。