Department of Community Medicine, West Virginia University School of Medicine, Morgantown, WV 26506, USA.
Int J Endocrinol. 2011;2011:604715. doi: 10.1155/2011/604715. Epub 2011 Nov 2.
Serum uric acid has been shown to be associated with cardiovascular disease, hypertension, and chronic kidney disease in previous studies. However, few studies have examined the association between serum uric acid and diabetes mellitus and their findings are not consistent. Therefore, we examined the association between serum uric acid levels and diabetes mellitus in participants from the third National Health and Nutrition Examination Survey (n = 18, 825, 52.5% women). Serum uric acid levels were categorized into quartiles. Diabetes mellitus was defined as fasting glucose ≥126 mg/dL, nonfasting glucose ≥200 mg/dL, or use of oral hypoglycemic medication or insulin (n = 395). In multivariable logistic regression models, we found that higher serum uric acid levels were inversely associated with diabetes mellitus after adjusting for age, sex, race/ethnicity, education, smoking, alcohol intake, body mass index, hypertension, and serum cholesterol. Compared to quartile 1 of serum uric acid, the odds ratio (95% confidence interval) of diabetes mellitus was 0.48 (0.35-0.66; P trend <0.0001). The results were consistent in subgroup analysis by gender and hypertension status. Higher serum uric acid levels were inversely associated with diabetes mellitus in a representative sample of US adults.
在之前的研究中，血清尿酸已被证明与心血管疾病、高血压和慢性肾脏病有关。然而，很少有研究检查血清尿酸与糖尿病之间的关联，而且它们的发现并不一致。因此，我们在来自第三次全国健康和营养检查调查的参与者中检查了血清尿酸水平与糖尿病之间的关联（n=18825，女性占 52.5%）。将血清尿酸水平分为四组。糖尿病定义为空腹血糖≥126mg/dL、非空腹血糖≥200mg/dL、或使用口服降糖药或胰岛素（n=395）。在多变量逻辑回归模型中，我们发现，在校正年龄、性别、种族/民族、教育、吸烟、饮酒、体重指数、高血压和血清胆固醇后，较高的血清尿酸水平与糖尿病呈负相关。与血清尿酸第 1 四分位数相比，糖尿病的比值比（95%置信区间）为 0.48（0.35-0.66；P 趋势<0.0001）。按性别和高血压状况进行的亚组分析结果一致。在代表性的美国成年人样本中，较高的血清尿酸水平与糖尿病呈负相关。
