Peninsula Medical School, University of Exeter, St Luke's Campus, Magdalen Road, Exeter, Devon, EX1 2LU, UK.
Expert Rev Clin Pharmacol. 2011 Jan;4(1):13-32. doi: 10.1586/ecp.10.134.
Hydrogen sulfide is rapidly gaining ground as a physiological mediator of inflammation, but there is no clear consensus as to its precise role in inflammatory signaling. This article discusses the disparate anti-inflammatory ('the good') and proinflammatory ('the bad') effects of endogenous and pharmacological H(2)S in disparate animal model and cell culture systems. We also discuss 'the ugly', such as problems of using wholly specific inhibitors of enzymatic H(2)S synthesis, and the use of pharmacological donor compounds, which release H(2)S too quickly to be physiologically representative of endogenous H(2)S synthesis. Furthermore, recently developed slow-release H(2)S donors, which offer a more physiological approach to understanding the complex role of H(2)S in acute and chronic inflammation ('the promising') are discussed.
硫化氢作为炎症的生理介质迅速得到认可，但对于其在炎症信号中的确切作用仍没有明确共识。本文讨论了内源性和药理学 H2S 在不同动物模型和细胞培养系统中表现出的不同的抗炎（“好”）和促炎（“坏”）作用。我们还讨论了“丑陋”的一面，例如完全特异性抑制酶促 H2S 合成抑制剂的使用问题，以及药理学供体化合物的使用问题，这些化合物释放 H2S 的速度太快，无法代表内源性 H2S 合成的生理情况。此外，还讨论了最近开发的 H2S 缓释放供体，这些供体提供了一种更具生理学意义的方法来理解 H2S 在急性和慢性炎症中的复杂作用（“有前途”）。
