Holroyd S, DePaulo J R
Department of Psychiatry and Behavioral Sciences, Johns Hopkins Hospital, Baltimore, Md 21205.
J Clin Psychiatry. 1990 Oct;51(10):407-9.
Despite an extensive literature examining the relationship between Crohn's disease and psychiatric illness, there is only one published report of mania in a patient with Crohn's disease. The authors describe seven patients, six men and one woman, with both bipolar disorder and Crohn's disease. The age at onset of Crohn's disease was highly correlated with the age at onset of affective disorder (r = .89, p = .016) and mania (r = .79, p = .06). Four patients received prednisone therapy for Crohn's disease from 3 to 52 weeks before their first manic episode. The authors discuss the relationship of the two illnesses, including possible common provoking factors, the possible role of steroids, and the genetics of the disorders.
尽管有大量文献研究克罗恩病与精神疾病之间的关系，但仅有一篇关于克罗恩病患者出现躁狂症的发表报告。作者描述了七名患者，六名男性和一名女性，他们同时患有双相情感障碍和克罗恩病。克罗恩病的发病年龄与情感障碍的发病年龄高度相关（r = 0.89，p = 0.016），与躁狂症的发病年龄也高度相关（r = 0.79，p = 0.06）。四名患者在首次躁狂发作前3至52周接受了针对克罗恩病的泼尼松治疗。作者讨论了这两种疾病之间的关系，包括可能的共同诱发因素、类固醇可能发挥的作用以及疾病的遗传学。
