P 物质-神经激肽-1 受体相互作用上调单核细胞组织因子。
Substance P-neurokinin-1 receptor interaction upregulates monocyte tissue factor.
机构信息
Department of Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, United States.
出版信息
J Neuroimmunol. 2012 Jan 18;242(1-2):1-8. doi: 10.1016/j.jneuroim.2011.10.012. Epub 2011 Nov 23.
Abstract
Monocytes play an important role in hemostasis. In this study, the prothrombotic effects of the neuropeptide substance P (SP) on human monocytes through neurokinin-1 receptor (NK1-R) were characterized. SP upregulated monocyte tissue factor (TF), the major coagulation cascade stimulator, in a concentration and time dependent manner. Specific inhibition of NK1-R completely blocked TF expression. Monocytes stimulated by SP released cytokines and chemokines. When monocytes were stimulated with cytokines or chemokines, TF was expressed by the cytokines (GM-CSF, IFN-γ and TNF-α). Cytokines may play a major role in the mechanism of SP induced monocyte TF expression. NK1-R antagonists (NK1-RA) may have a role in developing novel therapeutic approaches to patients vulnerable to vaso-occlusive disorders.
摘要
单核细胞在止血中发挥重要作用。本研究通过神经激肽-1 受体（NK1-R）探讨神经肽物质 P（SP）对人单核细胞的促血栓形成作用。SP 呈浓度和时间依赖性地上调单核细胞组织因子（TF），后者是主要的凝血级联刺激物。NK1-R 的特异性抑制完全阻断了 TF 的表达。SP 刺激的单核细胞释放细胞因子和趋化因子。当单核细胞被细胞因子或趋化因子刺激时，细胞因子（GM-CSF、IFN-γ 和 TNF-α）表达 TF。细胞因子可能在 SP 诱导单核细胞 TF 表达的机制中起主要作用。NK1-R 拮抗剂（NK1-RA）可能在开发针对易发生血管阻塞性疾病的患者的新型治疗方法方面发挥作用。
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