Nofziger Charity, Dossena Silvia, Suzuki Shoichi, Izuhara Kenji, Paulmichl Markus
Institute of Pharmacology and Toxicology, Paracelsus Medical University, Salzburg, Austria.
Cell Physiol Biochem. 2011;28(3):571-8. doi: 10.1159/000335115. Epub 2011 Nov 18.
The expression and function of the anion exchanger pendrin (SLC26A4) was thought to be limited mainly to the inner ear, kidney and thyroid. Recent data indicates that pendrin is also expressed in the bronchial epithelium following exposure to the T(H)2-type cytokines, interleukin (IL)-4 and IL-13. Expression of the transporter is also upregulated in bronchial asthma and chronic obstructive pulmonary disease. Both diseases involve respiratory inflammation leading to tissue destruction/remodeling and decreased airway function, and data so far indicate that increased pendrin expression and/or activity might contribute to their pathogenesis. In this review, we summarize data that have emerged within the past years aimed at revealing the role for pendrin in the airway epithelia.
阴离子交换蛋白pendrin（SLC26A4）的表达和功能曾被认为主要局限于内耳、肾脏和甲状腺。最近的数据表明，在暴露于辅助性T细胞2（TH2）型细胞因子白细胞介素（IL）-4和IL-13后，pendrin也在支气管上皮中表达。该转运蛋白的表达在支气管哮喘和慢性阻塞性肺疾病中也会上调。这两种疾病都涉及呼吸道炎症，导致组织破坏/重塑和气道功能下降，目前的数据表明，pendrin表达和/或活性增加可能有助于其发病机制。在本综述中，我们总结了过去几年出现的旨在揭示pendrin在气道上皮细胞中作用的数据。
