Pharmgenetix GmbH, A-5081 Niederalm, Austria.
Institute of Pharmacology and Toxicology, Paracelsus Medical University, A-5020 Salzburg, Austria.
Int J Mol Sci. 2019 Feb 9;20(3):731. doi: 10.3390/ijms20030731.
Pendrin (SLC26A4), a Cl/anion exchanger, is expressed at high levels in kidney, thyroid, and inner ear epithelia, where it has an essential role in bicarbonate secretion/chloride reabsorption, iodide accumulation, and endolymph ion balance, respectively. Pendrin is expressed at lower levels in other tissues, such as airways and esophageal epithelia, where it is transcriptionally regulated by the inflammatory cytokines interleukin (IL)-4 and IL-13 through a signal transducer and activator of transcription 6 (STAT6)-mediated pathway. In the airway epithelium, increased pendrin expression during inflammatory diseases leads to imbalances in airway surface liquid thickness and mucin release, while, in the esophageal epithelium, dysregulated pendrin expression is supposed to impact the intracellular pH regulation system. In this review, we discuss some of the recent findings on interleukin-mediated transcriptional regulation of pendrin and how this dysregulation impacts airway and esophagus epithelial homeostasis during inflammatory diseases.
Pendrin（SLC26A4）是一种 Cl-/阴离子交换器，在肾脏、甲状腺和内耳上皮细胞中高表达，在这些组织中，它分别在碳酸氢盐分泌/氯离子重吸收、碘积聚和内淋巴离子平衡中发挥重要作用。Pendrin 在其他组织（如气道和食管上皮细胞）中表达水平较低，在这些组织中，它通过转录因子 6（STAT6）介导的信号通路，受炎症细胞因子白细胞介素（IL）-4 和 IL-13 的转录调控。在气道上皮细胞中，炎症性疾病期间 Pendrin 表达增加会导致气道表面液体厚度和粘蛋白释放失衡，而在食管上皮细胞中，Pendrin 表达失调可能会影响细胞内 pH 调节系统。在这篇综述中，我们讨论了白细胞介素介导的 Pendrin 转录调控的一些最新发现，以及这种失调如何在炎症性疾病期间影响气道和食管上皮细胞的内稳态。
