Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Beomeo-ri, Mulgeum-eup, Yangsan, Gyeongsangnam-do, 626-770, South Korea.
Clin Exp Nephrol. 2012 Apr;16(2):329-32. doi: 10.1007/s10157-011-0562-6. Epub 2011 Nov 25.
We report a case of relapse of minimal change disease following infection with the influenza A (H1N1) virus responsible for the 2009 pandemic. A 22-year-old man who had been diagnosed with minimal change disease presented with systemic edema. He had achieved complete remission with an oral steroid (prednisolone 1 mg/kg/day) by the 17th day of administration. On the 27th day of prednisolone administration, he presented with a new onset of generalized edema after several days of productive coughing. His urine showed proteinuria (4+) with a protein/creatinine ratio (PCR) of 2852.1 mg/g. His nasal swab sample was positive for the 2009 pandemic influenza (H1N1) virus by real-time reverse-transcriptase polymerase chain reaction (RT-PCR). He received oseltamivir (150 mg/day) for 5 days. A day after completing the oseltamivir therapy, his proteinuria returned to a normal range; urinalysis was negative for protein with PCR 79.2 mg/g. One month later, the patient remained normal with no proteinuria.
我们报告了一例由 2009 年大流行的甲型流感（H1N1）病毒感染引起的微小病变病复发的病例。一名 22 岁男性被诊断患有微小病变病，在开始服用皮质类固醇（泼尼松龙 1mg/kg/天）的第 17 天，病情完全缓解。在服用泼尼松龙的第 27 天，他在连续几天咳嗽后出现全身性水肿。他的尿液蛋白（4+），蛋白/肌酐比值（PCR）为 2852.1mg/g。他的鼻拭子样本经实时逆转录聚合酶链反应（RT-PCR）检测为 2009 年大流行流感（H1N1）病毒阳性。他接受了奥司他韦（150mg/天）治疗 5 天。奥司他韦治疗结束后一天，他的蛋白尿恢复正常；尿蛋白检测为阴性，PCR 为 79.2mg/g。一个月后，患者情况仍然正常，没有蛋白尿。
