Department of Language, City University London, London, UK.
Arch Phys Med Rehabil. 2012 Jan;93(1 Suppl):S86-95. doi: 10.1016/j.apmr.2011.05.028. Epub 2011 Nov 25.
To determine factors associated with or predictive of poor health-related quality of life (HRQL) in people with aphasia poststroke. Better understanding of these factors can allow better targeting of rehabilitation programs.
Electronic databases, covering medical (eg, Medline, Excerpta Medica Database, Evidence-Based Medicine Reviews, Cumulative Index to Nursing and Allied Health Literature, Ovid, Allied and Complementary Medicine Database) and social sciences (eg, PsycINFO) were searched and key experts were approached.
Studies including specific information on the HRQL of people with aphasia poststroke using validated HRQL measures or established ways of analyzing qualitative data were included. Two reviewers independently screened studies against the eligibility criteria.
This was undertaken independently by 2 reviewers. Discrepancies were resolved by consensus. Quantitative studies were assessed for quality with Counsell and Dennis' critical appraisal tool for systematic review of prognostic models in acute stroke; qualitative studies with the Critical Appraisal Skills Program tool for qualitative research.
Fourteen research reports met the eligibility criteria. Because of their high heterogeneity, the data synthesis was narrative. The evidence is not strong enough to determine the main predictors of HRQL in people with aphasia. Still, emotional distress/depression, severity of aphasia and communication disability, other medical problems, activity limitations, and aspects of social network and support were important factors.
Emotional distress, aphasia severity, communication and activity limitations, other medical problems, and social factors affect HRQL. Stroke HRQL studies need to include people with aphasia and report separately on them, in order to determine the main predictors of their HRQL and to identify what interventions can best address them.
确定与脑卒中后失语症患者健康相关生活质量（HRQL）较差相关或可预测的因素。更好地了解这些因素可以使康复计划的目标更加明确。
电子数据库，涵盖医学（例如，Medline、Excerpta Medica Database、Evidence-Based Medicine Reviews、Cumulative Index to Nursing and Allied Health Literature、Ovid、Allied and Complementary Medicine Database）和社会科学（例如，PsycINFO），并联系了关键专家。
包括使用经过验证的 HRQL 测量或既定方法分析定性数据的脑卒中后失语症患者 HRQL 特定信息的研究被纳入。两位审查员独立筛选符合入选标准的研究。
这是由两位审查员独立进行的。如有分歧，则通过协商解决。对定量研究采用 Counsell 和 Dennis 的急性脑卒中预后模型系统评价的批判性评价工具进行质量评估；对定性研究采用批判性评估技能计划工具进行定性研究。
符合入选标准的研究报告有 14 篇。由于其高度异质性，数据综合是叙述性的。证据还不够有力，无法确定影响失语症患者 HRQL 的主要预测因素。然而，情绪困扰/抑郁、失语症严重程度和沟通障碍、其他医疗问题、活动受限以及社会网络和支持的某些方面是重要因素。
情绪困扰、失语症严重程度、沟通和活动受限、其他医疗问题以及社会因素会影响 HRQL。脑卒中 HRQL 研究需要纳入失语症患者，并单独报告他们，以便确定影响他们 HRQL 的主要预测因素，并确定哪些干预措施最能解决这些问题。
