Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.
Fitoterapia. 2012 Mar;83(2):298-302. doi: 10.1016/j.fitote.2011.11.009. Epub 2011 Nov 17.
Phytochemical investigation of Beilschmiedia alloiophylla has resulted in the isolation of one new alkaloid, 2-hydroxy-9-methoxyaporphine (1), and ten known natural products, laurotetanine (2), liriodenine (3), boldine (4), secoboldine (5), isoboldine (6), asimilobine (7), oreobeiline (8), 6-epioreobeiline (9), β-amyrone (10), and (S)-3-methoxynordomesticine (11). Chemical studies on the bark of B. kunstleri afforded compounds 2 and 4 along with one bisbenzylisoquinoline alkaloid, N-dimethylphyllocryptine (12). Structures of compounds 1-12 were elucidated on the basis of spectroscopic methods. All of these isolates were evaluated for their anti-acetylcholinesterase (AChE), anti-α-glucosidase, anti-leishmanial and anti-fungal activities. Compounds 1-12 exhibited strong to moderate bioactivities in aforementioned bioassays.
对异叶兔耳木的植物化学研究导致分离得到一个新的生物碱，2-羟基-9-甲氧基阿朴啡（1），和十个已知的天然产物，laurotetanine（2），紫堇灵（3），博多宁（4），secoboldine（5），异博多宁（6），asimiloine（7），oreobeiline（8），6-epioreobeiline（9），β-石竹烯（10）和（S）-3-甲氧基诺多林（11）。对 B. kunstleri 的树皮进行的化学研究得到了化合物 2 和 4，以及一个双苄基异喹啉生物碱，N-二甲基石蒜裂碱（12）。基于光谱方法阐明了化合物 1-12 的结构。所有这些分离物都在上述生物测定中评估了它们的抗乙酰胆碱酯酶（AChE），抗α-葡萄糖苷酶，抗利什曼原虫和抗真菌活性。化合物 1-12 在上述生物测定中表现出强到中等的生物活性。
