大叶楠树皮中的一种新原阿朴啡生物碱——大叶楠碱A
Grandine A, a new proaporphine alkaloid from the bark of Phoebe grandis.
作者信息
Mukhtar Mat Ropi, Aziz Ahmad Nazif, Thomas Noel F, Hadi A Hamid A, Litaudon Marc, Awang Khalijah
机构信息
Centre for Natural Products and Drug Discovery, Block D, Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
出版信息
Molecules. 2009 Mar 23;14(3):1227-33. doi: 10.3390/molecules14031227.
The stem bark of Phoebe grandis afforded one new oxoproaporphine; (-)-grandine A (1), along with six known isoquinoline alkaloids: (-)-8,9-dihydrolinearisine (2), boldine, norboldine, lauformine, scortechiniine A and scortechiniine B. In addition to that of the new compound, complete 1H- and 13C-NMR data of the tetrahydroproaporphine (-)-8,9-dihydrolinearisine (2) is also reported. The alkaloids' structures were elucidated primarily by means of high field 1D- and 2D-NMR and HRMS spectral data.
楠木的茎皮中分离得到一个新的氧化阿朴菲类生物碱；(-)-楠木碱A（1），以及六个已知的异喹啉生物碱：(-)-8,9-二氢去甲荷叶碱（2）、波尔定碱、去甲波尔定碱、劳伏明碱、斯科泰基尼碱A和斯科泰基尼碱B。除了新化合物的相关数据外，还报道了四氢阿朴菲类生物碱(-)-8,9-二氢去甲荷叶碱（2）完整的¹H-和¹³C-NMR数据。这些生物碱的结构主要通过高场一维和二维NMR以及高分辨质谱光谱数据进行阐明。
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